Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair

The most frequent rearrangement of the human MLL gene fuses MLL to AF4 resulting in high-risk infant B-cell acute lymphoblastic leukemia (B-ALL). MLL fusions are also hallmark oncogenic events in secondary acute myeloid leukemia. They are a direct consequence of mis-repaired DNA double strand breaks...

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Detalles Bibliográficos
Autores principales: Castaño, Julio, Herrero, Ana B., Bursen, Aldeheid, González, Federico, Marschalek, Rolf, Gutiérrez, Norma C., Menendez, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058691/
https://www.ncbi.nlm.nih.gov/pubmed/27119507
http://dx.doi.org/10.18632/oncotarget.8938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058691/
https://www.ncbi.nlm.nih.gov/pubmed/27119507
http://dx.doi.org/10.18632/oncotarget.8938

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