Cargando…
Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1
NLRP12 is a member of the Nod-like receptor (NLR). Previous studies have reported enhanced colitis-associated inflammatory responses in NLRP12-deficient mice. In this study, we sought to investigate the role of NLRP12 in DSS-stimulated proinflammatory response in dendritic cells and mice colitis, an...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058702/ https://www.ncbi.nlm.nih.gov/pubmed/27105524 http://dx.doi.org/10.18632/oncotarget.8872 |
_version_ | 1782459286072328192 |
---|---|
author | Shi, Fushan Yang, Yang Kouadir, Mohammed Xu, Wei Hu, Songhua Wang, Tiancheng |
author_facet | Shi, Fushan Yang, Yang Kouadir, Mohammed Xu, Wei Hu, Songhua Wang, Tiancheng |
author_sort | Shi, Fushan |
collection | PubMed |
description | NLRP12 is a member of the Nod-like receptor (NLR). Previous studies have reported enhanced colitis-associated inflammatory responses in NLRP12-deficient mice. In this study, we sought to investigate the role of NLRP12 in DSS-stimulated proinflammatory response in dendritic cells and mice colitis, and the molecular mechanisms involved in the development of the inflammation. Our results showed that down-regulation of NLRP12 is required for DSS-induced release of proinflammatory cytokines IL-1β and TNF-α; that PR domain zinc finger protein 1 (also known as Blimp-1) induces NLRP12 down-regulation during DSS-induced proinflammatory response and colitis; and that TLR4 is implicated in the up-regulation of Blimp-1 that led to the down-regulation of NLRP12 expression in DSS-induced colitis. Taken together, the results suggest that the TLR4-Blimp-1 axis promotes DSS induced experimental colitis through the down-regulation of NLRP12. |
format | Online Article Text |
id | pubmed-5058702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-50587022016-10-15 Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1 Shi, Fushan Yang, Yang Kouadir, Mohammed Xu, Wei Hu, Songhua Wang, Tiancheng Oncotarget Research Paper NLRP12 is a member of the Nod-like receptor (NLR). Previous studies have reported enhanced colitis-associated inflammatory responses in NLRP12-deficient mice. In this study, we sought to investigate the role of NLRP12 in DSS-stimulated proinflammatory response in dendritic cells and mice colitis, and the molecular mechanisms involved in the development of the inflammation. Our results showed that down-regulation of NLRP12 is required for DSS-induced release of proinflammatory cytokines IL-1β and TNF-α; that PR domain zinc finger protein 1 (also known as Blimp-1) induces NLRP12 down-regulation during DSS-induced proinflammatory response and colitis; and that TLR4 is implicated in the up-regulation of Blimp-1 that led to the down-regulation of NLRP12 expression in DSS-induced colitis. Taken together, the results suggest that the TLR4-Blimp-1 axis promotes DSS induced experimental colitis through the down-regulation of NLRP12. Impact Journals LLC 2016-04-20 /pmc/articles/PMC5058702/ /pubmed/27105524 http://dx.doi.org/10.18632/oncotarget.8872 Text en Copyright: © 2016 Shi et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Shi, Fushan Yang, Yang Kouadir, Mohammed Xu, Wei Hu, Songhua Wang, Tiancheng Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1 |
title | Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1 |
title_full | Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1 |
title_fullStr | Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1 |
title_full_unstemmed | Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1 |
title_short | Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1 |
title_sort | inflammasome-independent role of nlrp12 in suppressing colonic inflammation regulated by blimp-1 |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058702/ https://www.ncbi.nlm.nih.gov/pubmed/27105524 http://dx.doi.org/10.18632/oncotarget.8872 |
work_keys_str_mv | AT shifushan inflammasomeindependentroleofnlrp12insuppressingcolonicinflammationregulatedbyblimp1 AT yangyang inflammasomeindependentroleofnlrp12insuppressingcolonicinflammationregulatedbyblimp1 AT kouadirmohammed inflammasomeindependentroleofnlrp12insuppressingcolonicinflammationregulatedbyblimp1 AT xuwei inflammasomeindependentroleofnlrp12insuppressingcolonicinflammationregulatedbyblimp1 AT husonghua inflammasomeindependentroleofnlrp12insuppressingcolonicinflammationregulatedbyblimp1 AT wangtiancheng inflammasomeindependentroleofnlrp12insuppressingcolonicinflammationregulatedbyblimp1 |