Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5

In a mouse model for neuroendocrine tumors of the pancreas (PanNETs), liver metastasis occurred at a higher frequency in males. Male mice also had higher serum and intratumoral levels of the innate immunity protein complement C5. In mice that lost the ability to express complement C5, there was a lo...

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Detalles Bibliográficos
Autores principales: Contractor, Tanupriya, Kobayashi, Shinta, da Silva, Edaise, Clausen, Richard, Chan, Chang, Vosburgh, Evan, Tang, Laura H., Levine, Arnold J., Harris, Chris R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058703/
https://www.ncbi.nlm.nih.gov/pubmed/27105526
http://dx.doi.org/10.18632/oncotarget.8874

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