Cargando…

PCDH10 Interacts With hTERT and Negatively Regulates Telomerase Activity

Telomerase catalyzes telomeric DNA synthesis, an essential process to maintain the length of telomere for continuous cell proliferation and genomic stability. Telomerase is activated in gametes, stem cells, and most tumor cells, and its activity is tightly controlled by a catalytic human telomerase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Li-Na, Hua, Xing, Deng, Wu-Quan, Wu, Qi-Nan, Mei, Hao, Chen, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health 2015
Materias:	6600
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058908/ https://www.ncbi.nlm.nih.gov/pubmed/26683936 http://dx.doi.org/10.1097/MD.0000000000002230

Ejemplares similares

hTERT promotes cell adhesion and migration independent of telomerase activity
por: Liu, Haiying, et al.
Publicado: (2016)

Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancer
por: Yang, Ruozhu, et al.
Publicado: (2023)

Differential expression of telomerase reverse transcriptase (hTERT) in lung tumours
por: Lantuejoul, S, et al.
Publicado: (2004)

Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene
por: Ramlee, Muhammad Khairul, et al.
Publicado: (2016)

KLF4 downregulates hTERT expression and telomerase activity to inhibit lung carcinoma growth
por: Hu, Wenxian, et al.
Publicado: (2016)

Effects of hTERT transfection on the telomere and telomerase of Periplaneta americana cells in vitro
por: Ma, Chenjing, et al.
Publicado: (2023)

Human Telomerase Reverse Transcriptase (hTERT) Q169 Is Essential for Telomerase Function In Vitro and In Vivo
por: Wyatt, Haley D. M., et al.
Publicado: (2009)

Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT
por: Xi, Linghe, et al.
Publicado: (2014)

Many disease-associated variants of hTERT retain high telomerase enzymatic activity
por: Zaug, Arthur J., et al.
Publicado: (2013)

Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
por: Leão, Ricardo, et al.
Publicado: (2018)

Mechanism of Human Telomerase Reverse Transcriptase (hTERT) Regulation and Clinical Impacts in Leukemia
por: Yik, Mot Yee, et al.
Publicado: (2021)

Hormonal regulation of telomerase activity and hTERT expression in steroid-regulated tissues and cancer
por: Taheri, Mohammad, et al.
Publicado: (2022)

Quantitative relationship between functionally active telomerase and major telomerase components (hTERT and hTR) in acute leukaemia cells
por: Ohyashiki, J H, et al.
Publicado: (2005)

A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase
por: Killedar, Anagha, et al.
Publicado: (2015)

Tax alters telomerase activity through both quantitative and qualitative hTERT transcriptional dysregulations
por: Karam, Maroun, et al.
Publicado: (2011)

Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERT
por: Kellermann, Guillaume, et al.
Publicado: (2015)

Telomerase Gene (hTERT) and Survival: Results From Two Swedish Cohorts of Older Adults
por: Kalpouzos, Grégoria, et al.
Publicado: (2016)

Inhibition of hTERT/telomerase contributes to the antitumor activity of pristimerin in pancreatic ductal adenocarcinoma cells
por: DEEB, DORRAH, et al.
Publicado: (2015)

Insights into Telomerase/hTERT Alternative Splicing Regulation Using Bioinformatics and Network Analysis in Cancer
por: Ludlow, Andrew T., et al.
Publicado: (2019)

The Role of Alternative RNA Splicing in the Regulation of hTERT, Telomerase, and Telomeres: Implications for Cancer Therapeutics
por: Slusher, Aaron L., et al.
Publicado: (2020)

Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms
por: Xu, D, et al.
Publicado: (1999)

BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells
por: Renaud, Stéphanie, et al.
Publicado: (2011)

The antiretroviral agent saquinavir enhances hTERT expression and telomerase activity in human T leukaemia cells in vitro
por: Adamo, Riccardo, et al.
Publicado: (2013)

Naïve T-cells in Myelodysplastic Syndrome Display Intrinsic Human Telomerase Reverse Transcriptase (hTERT) Deficiency
por: Yang, Lili, et al.
Publicado: (2012)

The PinX1/NPM interaction associates with hTERT in early-S phase and facilitates telomerase activation
por: Ho, Sai-Tim, et al.
Publicado: (2019)

Alternative Splicing of hTERT Pre-mRNA: A Potential Strategy for the Regulation of Telomerase Activity
por: Liu, Xuewen, et al.
Publicado: (2017)

Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes
por: Plyasova, Anna A., et al.
Publicado: (2021)

Research Progress on G-Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (hTERT) Promoter
por: Gu, Wei, et al.
Publicado: (2022)

Copy-number-gain of telomerase reverse transcriptase (hTERT) is associated with an unfavorable prognosis in esophageal adenocarcinoma
por: Lyu, Su Ir, et al.
Publicado: (2023)

A Novel Long Non-Coding RNA in the hTERT Promoter Region Regulates hTERT Expression
por: Malhotra, Sanandan, et al.
Publicado: (2017)

Inhibition of Human Telomerase Reverse Transcritpase (hTERT) and Telomerase Activity by Curcumin in Human Mammary Epithelial and Breast Carcinoma Cell Lines
por: Ramachandran, Chappail, et al.
Publicado: (2001)

hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells
por: Chang, J T, et al.
Publicado: (2006)

Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer
por: Zhu, C-Q, et al.
Publicado: (2006)

The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization
por: Sealey, David C. F., et al.
Publicado: (2010)

An Improved Model for the hTERT Promoter Quadruplex
por: Chaires, Jonathan B., et al.
Publicado: (2014)

The intrabody targeting of hTERT attenuates the immortality of cancer cells
por: Zhu, Xiangying, et al.
Publicado: (2009)

HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT)
por: Kuhlmann, Anne-Sophie, et al.
Publicado: (2007)

Hypermethylation of the hTERT promoter inhibits the expression of telomerase activity in normal oral fibroblasts and senescent normal oral keratinocytes
por: Shin, K-H, et al.
Publicado: (2003)

Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene
por: Renaud, S., et al.
Publicado: (2007)

Lysine-Specific Demethylase 1 (LSD1) Is Required for the Transcriptional Repression of the Telomerase Reverse Transcriptase (hTERT) Gene
por: Zhu, Qingjun, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_5g4oeqdnolp66i7b0oq97ui59p