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The Correlations Between MRI Perfusion, Diffusion Parameters, and (18)F-FDG PET Metabolic Parameters in Primary Head-and-Neck Cancer: A Cross-Sectional Analysis in Single Institute
This study aimed to investigate the relationships among parameters from dynamic contrast-enhanced (DCE) MRI, diffusion-weighted MRI (DWI), and (18)F-fluorodeoxyglucose ((18)F-FDG) PET in patients with primary head-and-neck squamous cell carcinoma (HNSCC). A total of 34 patients with primary HNSCC un...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059009/ https://www.ncbi.nlm.nih.gov/pubmed/26632740 http://dx.doi.org/10.1097/MD.0000000000002141 |
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author | Han, Miran Kim, Sun Yong Lee, Su Jin Choi, Jin Wook |
author_facet | Han, Miran Kim, Sun Yong Lee, Su Jin Choi, Jin Wook |
author_sort | Han, Miran |
collection | PubMed |
description | This study aimed to investigate the relationships among parameters from dynamic contrast-enhanced (DCE) MRI, diffusion-weighted MRI (DWI), and (18)F-fluorodeoxyglucose ((18)F-FDG) PET in patients with primary head-and-neck squamous cell carcinoma (HNSCC). A total of 34 patients with primary HNSCC underwent DCE-MRI, DWI, and (18)F-FDG PET before treatment. The perfusion parameters (K(trans), K(transmax), K(ep), V(e), V(p), and AUC(60)) from DCE-MRI and ADC (ADC(mean), ADC(min)) values from DWI were calculated within the manually placed ROI around the main tumor. Standardized uptake value (SUV(max), SUV(mean)), metabolic tumor volume (MTV), and total lesion glycolysis (TLG = SUV(mean) × MTV) were calculated with thresholds of 3.0 SUV. The associations between parameters were evaluated by Pearson correlation analysis. Significant correlations were identified between K(trans) and K(ep) (r = 0.631), K(trans) and V(e) (r = 0.603), K(trans) and ADC(mean) (r = 0.438), K(transmax) and K(ep) (r = 0.667), K(transmax) and V(p) (r = 0.351), V(e) and AUC(60) (r = 0.364), V(e) and ADC(mean) (r = 0.590), and V(e) and ADC(min) (r = 0.361). ADC(min) was reversely correlated with TLG (r = –0.347). Tumor volume was significantly associated with K(transmax) (r = 0.348). The demonstrated relationships among parameters from DCE, DWI, and (18)F-FDG PET suggest complex interactions among tumor biologic characteristics. Each diagnostic technique may provide complementary information for HNSCC. |
format | Online Article Text |
id | pubmed-5059009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-50590092016-11-01 The Correlations Between MRI Perfusion, Diffusion Parameters, and (18)F-FDG PET Metabolic Parameters in Primary Head-and-Neck Cancer: A Cross-Sectional Analysis in Single Institute Han, Miran Kim, Sun Yong Lee, Su Jin Choi, Jin Wook Medicine (Baltimore) 6800 This study aimed to investigate the relationships among parameters from dynamic contrast-enhanced (DCE) MRI, diffusion-weighted MRI (DWI), and (18)F-fluorodeoxyglucose ((18)F-FDG) PET in patients with primary head-and-neck squamous cell carcinoma (HNSCC). A total of 34 patients with primary HNSCC underwent DCE-MRI, DWI, and (18)F-FDG PET before treatment. The perfusion parameters (K(trans), K(transmax), K(ep), V(e), V(p), and AUC(60)) from DCE-MRI and ADC (ADC(mean), ADC(min)) values from DWI were calculated within the manually placed ROI around the main tumor. Standardized uptake value (SUV(max), SUV(mean)), metabolic tumor volume (MTV), and total lesion glycolysis (TLG = SUV(mean) × MTV) were calculated with thresholds of 3.0 SUV. The associations between parameters were evaluated by Pearson correlation analysis. Significant correlations were identified between K(trans) and K(ep) (r = 0.631), K(trans) and V(e) (r = 0.603), K(trans) and ADC(mean) (r = 0.438), K(transmax) and K(ep) (r = 0.667), K(transmax) and V(p) (r = 0.351), V(e) and AUC(60) (r = 0.364), V(e) and ADC(mean) (r = 0.590), and V(e) and ADC(min) (r = 0.361). ADC(min) was reversely correlated with TLG (r = –0.347). Tumor volume was significantly associated with K(transmax) (r = 0.348). The demonstrated relationships among parameters from DCE, DWI, and (18)F-FDG PET suggest complex interactions among tumor biologic characteristics. Each diagnostic technique may provide complementary information for HNSCC. Wolters Kluwer Health 2015-10-30 /pmc/articles/PMC5059009/ /pubmed/26632740 http://dx.doi.org/10.1097/MD.0000000000002141 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 6800 Han, Miran Kim, Sun Yong Lee, Su Jin Choi, Jin Wook The Correlations Between MRI Perfusion, Diffusion Parameters, and (18)F-FDG PET Metabolic Parameters in Primary Head-and-Neck Cancer: A Cross-Sectional Analysis in Single Institute |
title | The Correlations Between MRI Perfusion, Diffusion Parameters, and (18)F-FDG PET Metabolic Parameters in Primary Head-and-Neck Cancer: A Cross-Sectional Analysis in Single Institute |
title_full | The Correlations Between MRI Perfusion, Diffusion Parameters, and (18)F-FDG PET Metabolic Parameters in Primary Head-and-Neck Cancer: A Cross-Sectional Analysis in Single Institute |
title_fullStr | The Correlations Between MRI Perfusion, Diffusion Parameters, and (18)F-FDG PET Metabolic Parameters in Primary Head-and-Neck Cancer: A Cross-Sectional Analysis in Single Institute |
title_full_unstemmed | The Correlations Between MRI Perfusion, Diffusion Parameters, and (18)F-FDG PET Metabolic Parameters in Primary Head-and-Neck Cancer: A Cross-Sectional Analysis in Single Institute |
title_short | The Correlations Between MRI Perfusion, Diffusion Parameters, and (18)F-FDG PET Metabolic Parameters in Primary Head-and-Neck Cancer: A Cross-Sectional Analysis in Single Institute |
title_sort | correlations between mri perfusion, diffusion parameters, and (18)f-fdg pet metabolic parameters in primary head-and-neck cancer: a cross-sectional analysis in single institute |
topic | 6800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059009/ https://www.ncbi.nlm.nih.gov/pubmed/26632740 http://dx.doi.org/10.1097/MD.0000000000002141 |
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