Cargando…

Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis

BACKGROUND: This research aims to assess the response to acid suppression therapy in gastroesophageal reflux disease (GERD)-related chronic laryngitis (CL). METHODS: Data were extracted from Web of Knowledge, Embase, and PubMed for English language article published up to March 2016. Pooled overall...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yue, Wu, Haitao, Zhou, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059042/
https://www.ncbi.nlm.nih.gov/pubmed/27749540
http://dx.doi.org/10.1097/MD.0000000000004868
_version_ 1782459364578164736
author Yang, Yue
Wu, Haitao
Zhou, Jian
author_facet Yang, Yue
Wu, Haitao
Zhou, Jian
author_sort Yang, Yue
collection PubMed
description BACKGROUND: This research aims to assess the response to acid suppression therapy in gastroesophageal reflux disease (GERD)-related chronic laryngitis (CL). METHODS: Data were extracted from Web of Knowledge, Embase, and PubMed for English language article published up to March 2016. Pooled overall response rate (ORR) rates were evaluated to determine acid suppression treatment efficacy. Random effects model was used with standard approaches to sensitivity analysis, quality assessment, heterogeneity, and exploration of publication bias. RESULTS: Pooled data from 21 reports (N = 2864, antireflux medicine: 2741; antireflux surgery: 123, study duration 4–108 week) were analyzed. With the random-effect model, the ORR was 66% (95% confidence interval [CI] 54%–78%). The ORRs were 80% for antireflux surgery (95% CI 67%–93%, 3 studies, 123 patients), whereas 64% for antireflux medicine (95% CI 50%–77%, 18 studies, 2741 patients), and the ORR was 70% (95% CI 55%–85%, 15 reports, 2731 patients) for >8 weeks’ therapy duration, whereas 57% (95% CI 48%–65%, 6 reports, 133 patients) for ≤8 weeks’ duration of therapy. CONCLUSIONS: Acid suppression seems to be an effective therapy for GERD-related CL. There was an increase in effect among patients with surgery therapeutic method and longer therapy duration.
format Online
Article
Text
id pubmed-5059042
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-50590422016-11-01 Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis Yang, Yue Wu, Haitao Zhou, Jian Medicine (Baltimore) 4500 BACKGROUND: This research aims to assess the response to acid suppression therapy in gastroesophageal reflux disease (GERD)-related chronic laryngitis (CL). METHODS: Data were extracted from Web of Knowledge, Embase, and PubMed for English language article published up to March 2016. Pooled overall response rate (ORR) rates were evaluated to determine acid suppression treatment efficacy. Random effects model was used with standard approaches to sensitivity analysis, quality assessment, heterogeneity, and exploration of publication bias. RESULTS: Pooled data from 21 reports (N = 2864, antireflux medicine: 2741; antireflux surgery: 123, study duration 4–108 week) were analyzed. With the random-effect model, the ORR was 66% (95% confidence interval [CI] 54%–78%). The ORRs were 80% for antireflux surgery (95% CI 67%–93%, 3 studies, 123 patients), whereas 64% for antireflux medicine (95% CI 50%–77%, 18 studies, 2741 patients), and the ORR was 70% (95% CI 55%–85%, 15 reports, 2731 patients) for >8 weeks’ therapy duration, whereas 57% (95% CI 48%–65%, 6 reports, 133 patients) for ≤8 weeks’ duration of therapy. CONCLUSIONS: Acid suppression seems to be an effective therapy for GERD-related CL. There was an increase in effect among patients with surgery therapeutic method and longer therapy duration. Wolters Kluwer Health 2016-10-07 /pmc/articles/PMC5059042/ /pubmed/27749540 http://dx.doi.org/10.1097/MD.0000000000004868 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 4500
Yang, Yue
Wu, Haitao
Zhou, Jian
Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis
title Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis
title_full Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis
title_fullStr Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis
title_full_unstemmed Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis
title_short Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis
title_sort efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059042/
https://www.ncbi.nlm.nih.gov/pubmed/27749540
http://dx.doi.org/10.1097/MD.0000000000004868
work_keys_str_mv AT yangyue efficacyofacidsuppressiontherapyingastroesophagealrefluxdiseaserelatedchroniclaryngitis
AT wuhaitao efficacyofacidsuppressiontherapyingastroesophagealrefluxdiseaserelatedchroniclaryngitis
AT zhoujian efficacyofacidsuppressiontherapyingastroesophagealrefluxdiseaserelatedchroniclaryngitis