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Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia

Colorectal cancer (CRC) is a major public health problem, and its incidence is rising in developing countries. However, studies characterizing CRC clinicopathological features in cases from developing countries are still lacking. The goal of this study was to evaluate clinicopathological and demogra...

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Autores principales: Bohorquez, Mabel, Sahasrabudhe, Ruta, Criollo, Angel, Sanabria-Salas, María Carolina, Vélez, Alejandro, Castro, Jorge Mario, Marquez, Juan Ricardo, Mateus, Gilbert, Bolaños, Fernando, Panqueva, Cesar, Restrepo, Jose Ignacio, Puerta, Juan Dario, Murillo, Raul, Bravo, María Mercedes, Hernández, Gustavo, Rios, Angela, Prieto, Rodrigo, Tomlinson, Ian, Echeverry, Magdalena, Carvajal-Carmona, Luis G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059046/
https://www.ncbi.nlm.nih.gov/pubmed/27749544
http://dx.doi.org/10.1097/MD.0000000000004883
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author Bohorquez, Mabel
Sahasrabudhe, Ruta
Criollo, Angel
Sanabria-Salas, María Carolina
Vélez, Alejandro
Castro, Jorge Mario
Marquez, Juan Ricardo
Mateus, Gilbert
Bolaños, Fernando
Panqueva, Cesar
Restrepo, Jose Ignacio
Puerta, Juan Dario
Murillo, Raul
Bravo, María Mercedes
Hernández, Gustavo
Rios, Angela
Prieto, Rodrigo
Tomlinson, Ian
Echeverry, Magdalena
Carvajal-Carmona, Luis G.
author_facet Bohorquez, Mabel
Sahasrabudhe, Ruta
Criollo, Angel
Sanabria-Salas, María Carolina
Vélez, Alejandro
Castro, Jorge Mario
Marquez, Juan Ricardo
Mateus, Gilbert
Bolaños, Fernando
Panqueva, Cesar
Restrepo, Jose Ignacio
Puerta, Juan Dario
Murillo, Raul
Bravo, María Mercedes
Hernández, Gustavo
Rios, Angela
Prieto, Rodrigo
Tomlinson, Ian
Echeverry, Magdalena
Carvajal-Carmona, Luis G.
author_sort Bohorquez, Mabel
collection PubMed
description Colorectal cancer (CRC) is a major public health problem, and its incidence is rising in developing countries. However, studies characterizing CRC clinicopathological features in cases from developing countries are still lacking. The goal of this study was to evaluate clinicopathological and demographic features in one of the largest CRC studies in Latin America. The study involved over 1525 CRC cases recruited in a multicenter study in Colombia between 2005 and 2014 as part of ongoing genetic and epidemiological studies. We gathered clinicopathological data such as age at diagnosis, sex, body mass index, tobacco and alcohol consumption, family history of cancer, and tumor features including location, histological type, and stage. Statistical analyses were performed to test the association between age of onset, sex, and clinical manifestations. The average age at CRC diagnosis was 57.4 years, with 26.5% of cases having early-onset CRC (diagnosed by age 50 years). Most cases were women (53.2%; P = 0.009), 49.2% were overweight or obese, 49.1% were regular alcohol drinkers, 52% were smokers/former smokers, and 12.2% reported relatives with cancer. Most tumors in the study were located in the rectum (42.7%), were adenocarcinomas (91.5%), and had advanced stage (T3–T4, 79.8%). Comparisons by sex found that male cases were more likely to be obese (36.5% vs 31.1%; P = 0.001), less likely to have a family history of cancer (9.7% vs 15.3%; P = 0.016), and more likely to have advanced-stage tumors (83.9% vs 76.1%; P = 0.036). Comparisons by age of onset found that early-onset cases were more likely to be women (59.3% vs 51.0%; P = 0.005) and report a family history of cancer (17.4% vs 10.2%; P = 0.001). To our knowledge, our study is the largest report of clinicopathological characterization of Hispanic CRC cases, and we suggest that further studies are needed to understand CRC etiology in diverse Hispanic populations.
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spelling pubmed-50590462016-11-01 Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia Bohorquez, Mabel Sahasrabudhe, Ruta Criollo, Angel Sanabria-Salas, María Carolina Vélez, Alejandro Castro, Jorge Mario Marquez, Juan Ricardo Mateus, Gilbert Bolaños, Fernando Panqueva, Cesar Restrepo, Jose Ignacio Puerta, Juan Dario Murillo, Raul Bravo, María Mercedes Hernández, Gustavo Rios, Angela Prieto, Rodrigo Tomlinson, Ian Echeverry, Magdalena Carvajal-Carmona, Luis G. Medicine (Baltimore) 4700 Colorectal cancer (CRC) is a major public health problem, and its incidence is rising in developing countries. However, studies characterizing CRC clinicopathological features in cases from developing countries are still lacking. The goal of this study was to evaluate clinicopathological and demographic features in one of the largest CRC studies in Latin America. The study involved over 1525 CRC cases recruited in a multicenter study in Colombia between 2005 and 2014 as part of ongoing genetic and epidemiological studies. We gathered clinicopathological data such as age at diagnosis, sex, body mass index, tobacco and alcohol consumption, family history of cancer, and tumor features including location, histological type, and stage. Statistical analyses were performed to test the association between age of onset, sex, and clinical manifestations. The average age at CRC diagnosis was 57.4 years, with 26.5% of cases having early-onset CRC (diagnosed by age 50 years). Most cases were women (53.2%; P = 0.009), 49.2% were overweight or obese, 49.1% were regular alcohol drinkers, 52% were smokers/former smokers, and 12.2% reported relatives with cancer. Most tumors in the study were located in the rectum (42.7%), were adenocarcinomas (91.5%), and had advanced stage (T3–T4, 79.8%). Comparisons by sex found that male cases were more likely to be obese (36.5% vs 31.1%; P = 0.001), less likely to have a family history of cancer (9.7% vs 15.3%; P = 0.016), and more likely to have advanced-stage tumors (83.9% vs 76.1%; P = 0.036). Comparisons by age of onset found that early-onset cases were more likely to be women (59.3% vs 51.0%; P = 0.005) and report a family history of cancer (17.4% vs 10.2%; P = 0.001). To our knowledge, our study is the largest report of clinicopathological characterization of Hispanic CRC cases, and we suggest that further studies are needed to understand CRC etiology in diverse Hispanic populations. Wolters Kluwer Health 2016-10-07 /pmc/articles/PMC5059046/ /pubmed/27749544 http://dx.doi.org/10.1097/MD.0000000000004883 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 4700
Bohorquez, Mabel
Sahasrabudhe, Ruta
Criollo, Angel
Sanabria-Salas, María Carolina
Vélez, Alejandro
Castro, Jorge Mario
Marquez, Juan Ricardo
Mateus, Gilbert
Bolaños, Fernando
Panqueva, Cesar
Restrepo, Jose Ignacio
Puerta, Juan Dario
Murillo, Raul
Bravo, María Mercedes
Hernández, Gustavo
Rios, Angela
Prieto, Rodrigo
Tomlinson, Ian
Echeverry, Magdalena
Carvajal-Carmona, Luis G.
Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia
title Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia
title_full Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia
title_fullStr Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia
title_full_unstemmed Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia
title_short Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia
title_sort clinical manifestations of colorectal cancer patients from a large multicenter study in colombia
topic 4700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059046/
https://www.ncbi.nlm.nih.gov/pubmed/27749544
http://dx.doi.org/10.1097/MD.0000000000004883
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