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Sexually dimorphic neuronal responses to social isolation
Many species use social networks to buffer the effects of stress. The mere absence of a social network, however, may also be stressful. We examined neuroendocrine, PVN CRH neurons and report that social isolation alters the intrinsic properties of these cells in sexually dimorphic fashion. Specifica...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059136/ https://www.ncbi.nlm.nih.gov/pubmed/27725087 http://dx.doi.org/10.7554/eLife.18726 |
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author | Senst, Laura Baimoukhametova, Dinara Sterley, Toni-Lee Bains, Jaideep Singh |
author_facet | Senst, Laura Baimoukhametova, Dinara Sterley, Toni-Lee Bains, Jaideep Singh |
author_sort | Senst, Laura |
collection | PubMed |
description | Many species use social networks to buffer the effects of stress. The mere absence of a social network, however, may also be stressful. We examined neuroendocrine, PVN CRH neurons and report that social isolation alters the intrinsic properties of these cells in sexually dimorphic fashion. Specifically, isolating preadolescent female mice from littermates for <24 hr increased first spike latency (FSL) and decreased excitability of CRH neurons. These changes were not evident in age-matched males. By contrast, subjecting either males (isolated or grouped) or group housed females to acute physical stress (swim), increased FSL. The increase in FSL following either social isolation or acute physical stress was blocked by the glucocorticoid synthesis inhibitor, metyrapone and mimicked by exogenous corticosterone. The increase in FSL results in a decrease in the excitability of CRH neurons. Our observations demonstrate that social isolation, but not acute physical stress has sex-specific effects on PVN CRH neurons. DOI: http://dx.doi.org/10.7554/eLife.18726.001 |
format | Online Article Text |
id | pubmed-5059136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-50591362016-10-12 Sexually dimorphic neuronal responses to social isolation Senst, Laura Baimoukhametova, Dinara Sterley, Toni-Lee Bains, Jaideep Singh eLife Neuroscience Many species use social networks to buffer the effects of stress. The mere absence of a social network, however, may also be stressful. We examined neuroendocrine, PVN CRH neurons and report that social isolation alters the intrinsic properties of these cells in sexually dimorphic fashion. Specifically, isolating preadolescent female mice from littermates for <24 hr increased first spike latency (FSL) and decreased excitability of CRH neurons. These changes were not evident in age-matched males. By contrast, subjecting either males (isolated or grouped) or group housed females to acute physical stress (swim), increased FSL. The increase in FSL following either social isolation or acute physical stress was blocked by the glucocorticoid synthesis inhibitor, metyrapone and mimicked by exogenous corticosterone. The increase in FSL results in a decrease in the excitability of CRH neurons. Our observations demonstrate that social isolation, but not acute physical stress has sex-specific effects on PVN CRH neurons. DOI: http://dx.doi.org/10.7554/eLife.18726.001 eLife Sciences Publications, Ltd 2016-10-11 /pmc/articles/PMC5059136/ /pubmed/27725087 http://dx.doi.org/10.7554/eLife.18726 Text en © 2016, Senst et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Senst, Laura Baimoukhametova, Dinara Sterley, Toni-Lee Bains, Jaideep Singh Sexually dimorphic neuronal responses to social isolation |
title | Sexually dimorphic neuronal responses to social isolation |
title_full | Sexually dimorphic neuronal responses to social isolation |
title_fullStr | Sexually dimorphic neuronal responses to social isolation |
title_full_unstemmed | Sexually dimorphic neuronal responses to social isolation |
title_short | Sexually dimorphic neuronal responses to social isolation |
title_sort | sexually dimorphic neuronal responses to social isolation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059136/ https://www.ncbi.nlm.nih.gov/pubmed/27725087 http://dx.doi.org/10.7554/eLife.18726 |
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