Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system

CRISPR–Cas systems provide bacteria with adaptive immunity against foreign nucleic acids by acquiring short, invader-derived sequences called spacers. Here, we use high-throughput sequencing to analyse millions of spacer acquisition events in wild-type populations of Pectobacterium atrosepticum. Pla...

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Detalles Bibliográficos
Autores principales: Staals, Raymond H. J., Jackson, Simon A., Biswas, Ambarish, Brouns, Stan J. J., Brown, Chris M., Fineran, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059440/
https://www.ncbi.nlm.nih.gov/pubmed/27694798
http://dx.doi.org/10.1038/ncomms12853

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