Divergent effects of central melanocortin signalling on fat and sucrose preference in humans

Melanocortin-4-receptor (MC4R)-expressing neurons modulate food intake and preference in rodents but their role in human food preference is unknown. Here we show that compared with lean and weight-matched controls, MC4R deficient individuals exhibited a markedly increased preference for high fat, bu...

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Autores principales: van der Klaauw, Agatha A., Keogh, Julia M., Henning, Elana, Stephenson, Cheryl, Kelway, Sarah, Trowse, Victoria M., Subramanian, Naresh, O'Rahilly, Stephen, Fletcher, Paul C., Farooqi, I. Sadaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059464/
https://www.ncbi.nlm.nih.gov/pubmed/27701398
http://dx.doi.org/10.1038/ncomms13055
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author van der Klaauw, Agatha A.
Keogh, Julia M.
Henning, Elana
Stephenson, Cheryl
Kelway, Sarah
Trowse, Victoria M.
Subramanian, Naresh
O'Rahilly, Stephen
Fletcher, Paul C.
Farooqi, I. Sadaf
author_facet van der Klaauw, Agatha A.
Keogh, Julia M.
Henning, Elana
Stephenson, Cheryl
Kelway, Sarah
Trowse, Victoria M.
Subramanian, Naresh
O'Rahilly, Stephen
Fletcher, Paul C.
Farooqi, I. Sadaf
author_sort van der Klaauw, Agatha A.
collection PubMed
description Melanocortin-4-receptor (MC4R)-expressing neurons modulate food intake and preference in rodents but their role in human food preference is unknown. Here we show that compared with lean and weight-matched controls, MC4R deficient individuals exhibited a markedly increased preference for high fat, but a significantly reduced preference for high sucrose food. These effects mirror those in Mc4r null rodents and provide evidence for a central molecular circuit influencing human macronutrient preference.
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spelling pubmed-50594642016-10-26 Divergent effects of central melanocortin signalling on fat and sucrose preference in humans van der Klaauw, Agatha A. Keogh, Julia M. Henning, Elana Stephenson, Cheryl Kelway, Sarah Trowse, Victoria M. Subramanian, Naresh O'Rahilly, Stephen Fletcher, Paul C. Farooqi, I. Sadaf Nat Commun Article Melanocortin-4-receptor (MC4R)-expressing neurons modulate food intake and preference in rodents but their role in human food preference is unknown. Here we show that compared with lean and weight-matched controls, MC4R deficient individuals exhibited a markedly increased preference for high fat, but a significantly reduced preference for high sucrose food. These effects mirror those in Mc4r null rodents and provide evidence for a central molecular circuit influencing human macronutrient preference. Nature Publishing Group 2016-10-04 /pmc/articles/PMC5059464/ /pubmed/27701398 http://dx.doi.org/10.1038/ncomms13055 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
van der Klaauw, Agatha A.
Keogh, Julia M.
Henning, Elana
Stephenson, Cheryl
Kelway, Sarah
Trowse, Victoria M.
Subramanian, Naresh
O'Rahilly, Stephen
Fletcher, Paul C.
Farooqi, I. Sadaf
Divergent effects of central melanocortin signalling on fat and sucrose preference in humans
title Divergent effects of central melanocortin signalling on fat and sucrose preference in humans
title_full Divergent effects of central melanocortin signalling on fat and sucrose preference in humans
title_fullStr Divergent effects of central melanocortin signalling on fat and sucrose preference in humans
title_full_unstemmed Divergent effects of central melanocortin signalling on fat and sucrose preference in humans
title_short Divergent effects of central melanocortin signalling on fat and sucrose preference in humans
title_sort divergent effects of central melanocortin signalling on fat and sucrose preference in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059464/
https://www.ncbi.nlm.nih.gov/pubmed/27701398
http://dx.doi.org/10.1038/ncomms13055
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