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Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling

We report that back-propagating action potentials (bAPs) are not simply digital feedback signals in dendrites but also carry analogue information about the overall state of neurons. Analogue information about the somatic membrane potential within a physiological range (from −78 to −64 mV) is retaine...

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Autores principales: Brunner, János, Szabadics, János
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059477/
https://www.ncbi.nlm.nih.gov/pubmed/27703164
http://dx.doi.org/10.1038/ncomms13033
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author Brunner, János
Szabadics, János
author_facet Brunner, János
Szabadics, János
author_sort Brunner, János
collection PubMed
description We report that back-propagating action potentials (bAPs) are not simply digital feedback signals in dendrites but also carry analogue information about the overall state of neurons. Analogue information about the somatic membrane potential within a physiological range (from −78 to −64 mV) is retained by bAPs of dentate gyrus granule cells as different repolarization speeds in proximal dendrites and as different peak amplitudes in distal regions. These location-dependent waveform changes are reflected by local calcium influx, leading to proximal enhancement and distal attenuation during somatic hyperpolarization. The functional link between these retention and readout mechanisms of the analogue content of bAPs critically depends on high-voltage-activated, inactivating calcium channels. The hybrid bAP and calcium mechanisms report the phase of physiological somatic voltage fluctuations and modulate long-term synaptic plasticity in distal dendrites. Thus, bAPs are hybrid signals that relay somatic analogue information, which is detected by the dendrites in a location-dependent manner.
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spelling pubmed-50594772016-10-26 Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling Brunner, János Szabadics, János Nat Commun Article We report that back-propagating action potentials (bAPs) are not simply digital feedback signals in dendrites but also carry analogue information about the overall state of neurons. Analogue information about the somatic membrane potential within a physiological range (from −78 to −64 mV) is retained by bAPs of dentate gyrus granule cells as different repolarization speeds in proximal dendrites and as different peak amplitudes in distal regions. These location-dependent waveform changes are reflected by local calcium influx, leading to proximal enhancement and distal attenuation during somatic hyperpolarization. The functional link between these retention and readout mechanisms of the analogue content of bAPs critically depends on high-voltage-activated, inactivating calcium channels. The hybrid bAP and calcium mechanisms report the phase of physiological somatic voltage fluctuations and modulate long-term synaptic plasticity in distal dendrites. Thus, bAPs are hybrid signals that relay somatic analogue information, which is detected by the dendrites in a location-dependent manner. Nature Publishing Group 2016-10-05 /pmc/articles/PMC5059477/ /pubmed/27703164 http://dx.doi.org/10.1038/ncomms13033 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Brunner, János
Szabadics, János
Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling
title Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling
title_full Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling
title_fullStr Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling
title_full_unstemmed Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling
title_short Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling
title_sort analogue modulation of back-propagating action potentials enables dendritic hybrid signalling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059477/
https://www.ncbi.nlm.nih.gov/pubmed/27703164
http://dx.doi.org/10.1038/ncomms13033
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