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Refractive Errors and Concomitant Strabismus: A Systematic Review and Meta-analysis

This systematic review and meta-analysis is to evaluate the risk of development of concomitant strabismus due to refractive errors. Eligible studies published from 1946 to April 1, 2016 were identified from MEDLINE and EMBASE that evaluated any kinds of refractive errors (myopia, hyperopia, astigmat...

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Autores principales: Tang, Shu Min, Chan, Rachel Y. T., Bin Lin, Shi, Rong, Shi Song, Lau, Henry H. W., Lau, Winnie W. Y., Yip, Wilson W. K., Chen, Li Jia, Ko, Simon T. C., Yam, Jason C. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059633/
https://www.ncbi.nlm.nih.gov/pubmed/27731389
http://dx.doi.org/10.1038/srep35177
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author Tang, Shu Min
Chan, Rachel Y. T.
Bin Lin, Shi
Rong, Shi Song
Lau, Henry H. W.
Lau, Winnie W. Y.
Yip, Wilson W. K.
Chen, Li Jia
Ko, Simon T. C.
Yam, Jason C. S.
author_facet Tang, Shu Min
Chan, Rachel Y. T.
Bin Lin, Shi
Rong, Shi Song
Lau, Henry H. W.
Lau, Winnie W. Y.
Yip, Wilson W. K.
Chen, Li Jia
Ko, Simon T. C.
Yam, Jason C. S.
author_sort Tang, Shu Min
collection PubMed
description This systematic review and meta-analysis is to evaluate the risk of development of concomitant strabismus due to refractive errors. Eligible studies published from 1946 to April 1, 2016 were identified from MEDLINE and EMBASE that evaluated any kinds of refractive errors (myopia, hyperopia, astigmatism and anisometropia) as an independent factor for concomitant exotropia and concomitant esotropia. Totally 5065 published records were retrieved for screening, 157 of them eligible for detailed evaluation. Finally 7 population-based studies involving 23,541 study subjects met our criteria for meta-analysis. The combined OR showed that myopia was a risk factor for exotropia (OR: 5.23, P = 0.0001). We found hyperopia had a dose-related effect for esotropia (OR for a spherical equivalent [SE] of 2–3 diopters [D]: 10.16, P = 0.01; OR for an SE of 3-4D: 17.83, P < 0.0001; OR for an SE of 4-5D: 41.01, P < 0.0001; OR for an SE of ≥5D: 162.68, P < 0.0001). Sensitivity analysis indicated our results were robust. Results of this study confirmed myopia as a risk for concomitant exotropia and identified a dose-related effect for hyperopia as a risk of concomitant esotropia.
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spelling pubmed-50596332016-10-24 Refractive Errors and Concomitant Strabismus: A Systematic Review and Meta-analysis Tang, Shu Min Chan, Rachel Y. T. Bin Lin, Shi Rong, Shi Song Lau, Henry H. W. Lau, Winnie W. Y. Yip, Wilson W. K. Chen, Li Jia Ko, Simon T. C. Yam, Jason C. S. Sci Rep Article This systematic review and meta-analysis is to evaluate the risk of development of concomitant strabismus due to refractive errors. Eligible studies published from 1946 to April 1, 2016 were identified from MEDLINE and EMBASE that evaluated any kinds of refractive errors (myopia, hyperopia, astigmatism and anisometropia) as an independent factor for concomitant exotropia and concomitant esotropia. Totally 5065 published records were retrieved for screening, 157 of them eligible for detailed evaluation. Finally 7 population-based studies involving 23,541 study subjects met our criteria for meta-analysis. The combined OR showed that myopia was a risk factor for exotropia (OR: 5.23, P = 0.0001). We found hyperopia had a dose-related effect for esotropia (OR for a spherical equivalent [SE] of 2–3 diopters [D]: 10.16, P = 0.01; OR for an SE of 3-4D: 17.83, P < 0.0001; OR for an SE of 4-5D: 41.01, P < 0.0001; OR for an SE of ≥5D: 162.68, P < 0.0001). Sensitivity analysis indicated our results were robust. Results of this study confirmed myopia as a risk for concomitant exotropia and identified a dose-related effect for hyperopia as a risk of concomitant esotropia. Nature Publishing Group 2016-10-12 /pmc/articles/PMC5059633/ /pubmed/27731389 http://dx.doi.org/10.1038/srep35177 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Tang, Shu Min
Chan, Rachel Y. T.
Bin Lin, Shi
Rong, Shi Song
Lau, Henry H. W.
Lau, Winnie W. Y.
Yip, Wilson W. K.
Chen, Li Jia
Ko, Simon T. C.
Yam, Jason C. S.
Refractive Errors and Concomitant Strabismus: A Systematic Review and Meta-analysis
title Refractive Errors and Concomitant Strabismus: A Systematic Review and Meta-analysis
title_full Refractive Errors and Concomitant Strabismus: A Systematic Review and Meta-analysis
title_fullStr Refractive Errors and Concomitant Strabismus: A Systematic Review and Meta-analysis
title_full_unstemmed Refractive Errors and Concomitant Strabismus: A Systematic Review and Meta-analysis
title_short Refractive Errors and Concomitant Strabismus: A Systematic Review and Meta-analysis
title_sort refractive errors and concomitant strabismus: a systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059633/
https://www.ncbi.nlm.nih.gov/pubmed/27731389
http://dx.doi.org/10.1038/srep35177
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