Role of the pH in state-dependent blockade of hERG currents

Mutations that reduce inactivation of the voltage-gated Kv11.1 potassium channel (hERG) reduce binding for a number of blockers. State specific block of the inactivated state of hERG block may increase risks of drug-induced Torsade de pointes. In this study, molecular simulations of dofetilide bindi...

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Detalles Bibliográficos
Autores principales: Wang, Yibo, Guo, Jiqing, Perissinotti, Laura L., Lees-Miller, James, Teng, Guoqi, Durdagi, Serdar, Duff, Henry J., Noskov, Sergei Yu.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059635/
https://www.ncbi.nlm.nih.gov/pubmed/27731415
http://dx.doi.org/10.1038/srep32536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059635/
https://www.ncbi.nlm.nih.gov/pubmed/27731415
http://dx.doi.org/10.1038/srep32536

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