Islet-like organoids derived from human pluripotent stem cells efficiently function in the glucose responsiveness in vitro and in vivo

Insulin secretion is elaborately modulated in pancreatic ß cells within islets of three-dimensional (3D) structures. Using human pluripotent stem cells (hPSCs) to develop islet-like structures with insulin-producing ß cells for the treatment of diabetes is challenging. Here, we report that pancreati...

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Detalles Bibliográficos
Autores principales: Kim, Youngjin, Kim, Hyeongseok, Ko, Ung Hyun, Oh, Youjin, Lim, Ajin, Sohn, Jong-Woo, Shin, Jennifer H., Kim, Hail, Han, Yong-Mahn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059670/
https://www.ncbi.nlm.nih.gov/pubmed/27731367
http://dx.doi.org/10.1038/srep35145

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