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Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation

Selenocysteine is the only proteinogenic amino acid encoded by a recoded in-frame UGA codon that does not operate as the canonical opal stop codon. A specialized translation elongation factor, eEFSec in eukaryotes and SelB in prokaryotes, promotes selenocysteine incorporation into selenoproteins by...

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Detalles Bibliográficos
Autores principales:	Dobosz-Bartoszek, Malgorzata, Pinkerton, Mark H., Otwinowski, Zbyszek, Chakravarthy, Srinivas, Söll, Dieter, Copeland, Paul R., Simonović, Miljan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059743/ https://www.ncbi.nlm.nih.gov/pubmed/27708257 http://dx.doi.org/10.1038/ncomms12941

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