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An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism
The number of phalanges and joints are key features of digit ‘identity' and are central to limb functionality and evolutionary adaptation. Prior chick work indicated that digit phalanges and their associated joints arise in a different manner than the more sparsely jointed long bones, and their...
Autores principales: | Huang, Bau-Lin, Trofka, Anna, Furusawa, Aki, Norrie, Jacqueline L., Rabinowitz, Adam H., Vokes, Steven A., Mark Taketo, M., Zakany, Jozsef, Mackem, Susan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059757/ https://www.ncbi.nlm.nih.gov/pubmed/27713395 http://dx.doi.org/10.1038/ncomms12903 |
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