Bimodal antagonism of PKA signalling by ARHGAP36

Protein kinase A is a key mediator of cAMP signalling downstream of G-protein-coupled receptors, a signalling pathway conserved in all eukaryotes. cAMP binding to the regulatory subunits (PKAR) relieves their inhibition of the catalytic subunits (PKAC). Here we report that ARHGAP36 combines two dist...

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Detalles Bibliográficos
Autores principales: Eccles, Rebecca L., Czajkowski, Maciej T., Barth, Carolin, Müller, Paul Markus, McShane, Erik, Grunwald, Stephan, Beaudette, Patrick, Mecklenburg, Nora, Volkmer, Rudolf, Zühlke, Kerstin, Dittmar, Gunnar, Selbach, Matthias, Hammes, Annette, Daumke, Oliver, Klussmann, Enno, Urbé, Sylvie, Rocks, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059767/
https://www.ncbi.nlm.nih.gov/pubmed/27713425
http://dx.doi.org/10.1038/ncomms12963

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