Cargando…

Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids

The pyridine ring is a potent pharmacophore in alkaloid natural products. Nonetheless, its biosynthetic pathways are poorly understood. Rubrolones A and B are tropolone alkaloid natural products possessing a unique tetra-substituted pyridine moiety. Here, we report the gene cluster and propose a bio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Yijun, Yang, Jing, Yu, Zhiyin, Yu, Mingming, Ma, Ya-Tuan, Wang, Li, Su, Can, Luo, Jianying, Horsman, Geoffrey P., Huang, Sheng-Xiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059770/ https://www.ncbi.nlm.nih.gov/pubmed/27713400 http://dx.doi.org/10.1038/ncomms13083

Ejemplares similares

Dihydroisatropolone C from Streptomyces and Its Implication in Tropolone-Ring Construction for Isatropolone Biosynthesis
por: Liu, Jiachang, et al.
Publicado: (2022)

Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation
por: Huang, Jian-Ping, et al.
Publicado: (2019)

Synthetic Biology Driven Biosynthesis of Unnatural Tropolone Sesquiterpenoids
por: Schotte, Carsten, et al.
Publicado: (2020)

Biosynthesis of Antibacterial Iron-Chelating Tropolones in Aspergillus nidulans as Response to Glycopeptide-Producing Streptomycetes
por: Gerke, Jennifer, et al.
Publicado: (2022)

5-(Phenyldiazenyl)tropolone
por: Hill, Tania N., et al.
Publicado: (2012)

Stereochemical and Biosynthetic Rationalisation of the Tropolone Sesquiterpenoids
por: Li, Lei, et al.
Publicado: (2022)

Indole-3-Acetic Acid Produced by Burkholderia heleia Acts as a Phenylacetic Acid Antagonist to Disrupt Tropolone Biosynthesis in Burkholderia plantarii
por: Wang, Mengcen, et al.
Publicado: (2016)

Enzymatic one-step ring contraction for quinolone biosynthesis
por: Kishimoto, Shinji, et al.
Publicado: (2018)

Corrigendum: Indole-3-Acetic Acid Produced by Burkholderia heleia Acts as a Phenylacetic Acid Antagonist to Disrupt Tropolone Biosynthesis in Burkholderia plantarii
por: Wang, Mengcen, et al.
Publicado: (2016)

Ring-Polymer Instanton Tunneling Splittings of Tropolone and Isotopomers using a Δ-Machine Learned CCSD(T) Potential: Theory and Experiment Shake Hands
por: Nandi, Apurba, et al.
Publicado: (2023)

Crystal and molecular structures of fac-[Re(Bid)(PPh(3))(CO)(3)] [Bid is tropolone (TropH) and tribromotropolone (TropBr(3)H)]
por: Schutte-Smith, Marietjie, et al.
Publicado: (2022)

Hinokitiol, a Natural Tropolone Derivative, Offers Neuroprotection from Thromboembolic Stroke In Vivo
por: Jayakumar, Thanasekaran, et al.
Publicado: (2013)

Deciphering the enzymatic mechanism of sugar ring contraction in UDP-apiose biosynthesis
por: Savino, Simone, et al.
Publicado: (2019)

Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells
por: Haney, Staci L., et al.
Publicado: (2017)

Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan
por: Wei, Xin, et al.
Publicado: (2017)

Regioselective approach to colchiceine tropolone ring functionalization at C(9) and C(10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs
por: Pyta, Krystian, et al.
Publicado: (2022)

Genomic and structural basis for evolution of tropane alkaloid biosynthesis
por: Wang, Yong-Jiang, et al.
Publicado: (2023)

Pyridine alkaloids with activity in the central nervous system
por: Lin, Simon X., et al.
Publicado: (2020)

Investigation on the Enzymatic Profile of Mulberry Alkaloids by Enzymatic Study and Molecular Docking
por: Liu, Zhihua, et al.
Publicado: (2019)

Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
por: Budihas, Scott R., et al.
Publicado: (2005)

Discovery and characterization of natural tropolones as inhibitors of the antibacterial target CapF from Staphylococcus aureus
por: Nakano, Koichiro, et al.
Publicado: (2015)

Gene mining and efficient biosynthesis of a fungal peptidyl alkaloid
por: Zhang, Chen, et al.
Publicado: (2020)

Discovery and biosynthesis of karnamicins as angiotensin converting enzyme inhibitors
por: Yu, Zhiyin, et al.
Publicado: (2023)

Sources, Transformations, Syntheses, and Bioactivities of Monoterpene Pyridine Alkaloids and Cyclopenta[c]pyridine Derivatives
por: Zhang, Xuejian, et al.
Publicado: (2022)

Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus
por: Zhu, Jianhua, et al.
Publicado: (2015)

2-Hetaryl-1,3-tropolones based on five-membered nitrogen heterocycles: synthesis, structure and properties
por: Sayapin, Yury A, et al.
Publicado: (2015)

Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus
por: Menéndez-Perdomo, Ivette M., et al.
Publicado: (2018)

Biosynthesis of medicinal tropane alkaloids in yeast
por: Srinivasan, Prashanth, et al.
Publicado: (2020)

Discovery and engineering of colchicine alkaloid biosynthesis
por: Nett, Ryan S., et al.
Publicado: (2020)

A Route to the C,D,E Ring System of the Aspidosperma Alkaloids
por: Giampa, Geoffrey M., et al.
Publicado: (2016)

Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii
por: Fan, Dongsheng, et al.
Publicado: (2016)

Crystal structure of 5-[2-(2,4,6-tribromophenyl)diazenyl]tropolone
por: Hill, Tania N., et al.
Publicado: (2018)

Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolone derivatives as new anti-cancer agents
por: Gusakov, Evgeniy A., et al.
Publicado: (2021)

The Biosynthesis of Enzymatically Oxidized Lipids
por: Hajeyah, Ali A., et al.
Publicado: (2020)

Biosynthetic access to the rare antiarose sugar via an unusual reductase-epimerase
por: Yan, Yijun, et al.
Publicado: (2020)

Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast
por: Bradley, Samuel A., et al.
Publicado: (2023)

Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production
por: Kohnen-Johannsen, Kathrin Laura, et al.
Publicado: (2019)

Evaluation of Biosynthetic Pathway and Engineered Biosynthesis of Alkaloids
por: Kishimoto, Shinji, et al.
Publicado: (2016)

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast
por: Li, Yanran, et al.
Publicado: (2016)

Chemical investigations into the biosynthesis of the gymnastatin and dankastatin alkaloids
por: Tong, Bingqi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_eg9q359e4jajkardou1th3uu3s