Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype

Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range of cancers. Indeed, aberrant activation of the Hh pathway occurring either by ligand-dependent or -independent mechanisms is a key driver in tumorigenesis. The smoothened (Smo) receptor is one of the main upstream...

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Detalles Bibliográficos
Autores principales: Infante, Paola, Alfonsi, Romina, Ingallina, Cinzia, Quaglio, Deborah, Ghirga, Francesca, D'Acquarica, Ilaria, Bernardi, Flavia, Di Magno, Laura, Canettieri, Gianluca, Screpanti, Isabella, Gulino, Alberto, Botta, Bruno, Mori, Mattia, Di Marcotullio, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059851/
https://www.ncbi.nlm.nih.gov/pubmed/27899820
http://dx.doi.org/10.1038/cddis.2016.195

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