Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents

Non-small cell lung cancer (NSCLC) has the highest incidence of cancer-related death worldwide and a high medical need for more effective therapies. Small-molecule inhibitors of the bromodomain and extra terminal domain (BET) family such as JQ1, I-BET762 and OTX-015 are active in a wide range of dif...

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Detalles Bibliográficos
Autores principales: Klingbeil, Olaf, Lesche, Ralf, Gelato, Kathy A, Haendler, Bernard, Lejeune, Pascale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059870/
https://www.ncbi.nlm.nih.gov/pubmed/27607580
http://dx.doi.org/10.1038/cddis.2016.271

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