The Fra-1–miR-134–SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells

The Fra-1 transcription factor is frequently upregulated in multiple types of tumors. Here we found that Fra-1 promotes miR-134 expression. miR-134 activates JNK and ERK by targeting SDS22, which in turn induces Fra-1 expression and leads to miR-134 upregulation. In addition, miR-134 augmented H2AX...

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Detalles Bibliográficos
Autores principales: Wu, Jianmin, Sun, Yimin, Zhang, Pei-Ying, Qian, Mengyao, Zhang, Hengchao, Chen, Xiao, Ma, Di, Xu, Yunsheng, Chen, Xiaoming, Tang, Kai-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059884/
https://www.ncbi.nlm.nih.gov/pubmed/27685628
http://dx.doi.org/10.1038/cddis.2016.289

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