A new high-throughput sequencing method for determining diversity and similarity of T cell receptor (TCR) α and β repertoires and identifying potential new invariant TCR α chains

BACKGROUND: High-throughput sequencing of T cell receptor (TCR) genes is a powerful tool for analyses of antigen specificity, clonality and diversity of T lymphocytes. Here, we developed a new TCR repertoire analysis method using 454 DNA sequencing technology in combination with an adaptor-ligation...

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Detalles Bibliográficos
Autores principales: Kitaura, Kazutaka, Shini, Tadasu, Matsutani, Takaji, Suzuki, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059964/
https://www.ncbi.nlm.nih.gov/pubmed/27729009
http://dx.doi.org/10.1186/s12865-016-0177-5

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