Oxidation increases the strength of the methionine-aromatic interaction

Oxidation of methionine disrupts the structure and function of a range of proteins, but little is understood about the chemistry that underlies these perturbations. Using quantum mechanical calculations, we show that oxidation increases the strength of the methionine-aromatic interaction motif—a dri...

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Detalles Bibliográficos
Autores principales: Lewis, Andrew K., Dunleavy, Katie, Senkow, Tiffany L., Her, Cheng, Horn, Benjamin T., Jersett, Mark A., Mahling, Ryan, McCarthy, Megan R., Perell, Gabriella T., Valley, Christopher C., Karim, Christine B., Gao, Jiali, Pomerantz, William C. K., Thomas, David D., Cembran, Alessandro, Hinderliter, Anne, Sachs, Jonathan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5060120/
https://www.ncbi.nlm.nih.gov/pubmed/27547920
http://dx.doi.org/10.1038/nchembio.2159

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