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Patterns of cortical thinning in nondemented Parkinson's disease patients

BACKGROUND: Clinical variability in the Parkinson's disease phenotype suggests the existence of disease subtypes. We investigated whether distinct anatomical patterns of atrophy can be identified in Parkinson's disease using a hypothesis‐free, data‐driven approach based on cortical thickne...

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Autores principales: Uribe, Carme, Segura, Barbara, Baggio, Hugo Cesar, Abos, Alexandra, Marti, Maria Jose, Valldeoriola, Francesc, Compta, Yaroslau, Bargallo, Nuria, Junque, Carme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061099/
https://www.ncbi.nlm.nih.gov/pubmed/27094093
http://dx.doi.org/10.1002/mds.26590
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author Uribe, Carme
Segura, Barbara
Baggio, Hugo Cesar
Abos, Alexandra
Marti, Maria Jose
Valldeoriola, Francesc
Compta, Yaroslau
Bargallo, Nuria
Junque, Carme
author_facet Uribe, Carme
Segura, Barbara
Baggio, Hugo Cesar
Abos, Alexandra
Marti, Maria Jose
Valldeoriola, Francesc
Compta, Yaroslau
Bargallo, Nuria
Junque, Carme
author_sort Uribe, Carme
collection PubMed
description BACKGROUND: Clinical variability in the Parkinson's disease phenotype suggests the existence of disease subtypes. We investigated whether distinct anatomical patterns of atrophy can be identified in Parkinson's disease using a hypothesis‐free, data‐driven approach based on cortical thickness data. METHODS: T1‐weighted 3‐tesla MRI and a comprehensive neuropsychological assessment were performed in a sample of 88 nondemented Parkinson's disease patients and 31 healthy controls. We performed a hierarchical cluster analysis of imaging data using Ward's linkage method. A general linear model with cortical thickness data was used to compare clustering groups. RESULTS: We observed 3 patterns of cortical thinning in patients when compared with healthy controls. Pattern 1 (n = 30, 34.09%) consisted of cortical atrophy in bilateral precentral gyrus, inferior and superior parietal lobules, cuneus, posterior cingulate, and parahippocampal gyrus. These patients showed worse cognitive performance when compared with controls and the other 2 patterns. Pattern 2 (n = 29, 32.95%) consisted of cortical atrophy involving occipital and frontal as well as superior parietal areas and included patients with younger age at onset. Finally, in pattern 3 (n = 29, 32.95%), there was no detectable cortical thinning. Patients in the 3 patterns did not differ in disease duration, motor severity, dopaminergic medication doses, or presence of mild cognitive impairment. CONCLUSIONS: Three cortical atrophy subtypes were identified in nondemented Parkinson's disease patients: (1) parieto‐temporal pattern of atrophy with worse cognitive performance, (2) occipital and frontal cortical atrophy and younger disease onset, and (3) patients without detectable cortical atrophy. These findings may help identify prognosis markers in Parkinson's disease. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society
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spelling pubmed-50610992016-10-19 Patterns of cortical thinning in nondemented Parkinson's disease patients Uribe, Carme Segura, Barbara Baggio, Hugo Cesar Abos, Alexandra Marti, Maria Jose Valldeoriola, Francesc Compta, Yaroslau Bargallo, Nuria Junque, Carme Mov Disord Research Articles BACKGROUND: Clinical variability in the Parkinson's disease phenotype suggests the existence of disease subtypes. We investigated whether distinct anatomical patterns of atrophy can be identified in Parkinson's disease using a hypothesis‐free, data‐driven approach based on cortical thickness data. METHODS: T1‐weighted 3‐tesla MRI and a comprehensive neuropsychological assessment were performed in a sample of 88 nondemented Parkinson's disease patients and 31 healthy controls. We performed a hierarchical cluster analysis of imaging data using Ward's linkage method. A general linear model with cortical thickness data was used to compare clustering groups. RESULTS: We observed 3 patterns of cortical thinning in patients when compared with healthy controls. Pattern 1 (n = 30, 34.09%) consisted of cortical atrophy in bilateral precentral gyrus, inferior and superior parietal lobules, cuneus, posterior cingulate, and parahippocampal gyrus. These patients showed worse cognitive performance when compared with controls and the other 2 patterns. Pattern 2 (n = 29, 32.95%) consisted of cortical atrophy involving occipital and frontal as well as superior parietal areas and included patients with younger age at onset. Finally, in pattern 3 (n = 29, 32.95%), there was no detectable cortical thinning. Patients in the 3 patterns did not differ in disease duration, motor severity, dopaminergic medication doses, or presence of mild cognitive impairment. CONCLUSIONS: Three cortical atrophy subtypes were identified in nondemented Parkinson's disease patients: (1) parieto‐temporal pattern of atrophy with worse cognitive performance, (2) occipital and frontal cortical atrophy and younger disease onset, and (3) patients without detectable cortical atrophy. These findings may help identify prognosis markers in Parkinson's disease. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society John Wiley and Sons Inc. 2016-04-20 2016-05 /pmc/articles/PMC5061099/ /pubmed/27094093 http://dx.doi.org/10.1002/mds.26590 Text en © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Uribe, Carme
Segura, Barbara
Baggio, Hugo Cesar
Abos, Alexandra
Marti, Maria Jose
Valldeoriola, Francesc
Compta, Yaroslau
Bargallo, Nuria
Junque, Carme
Patterns of cortical thinning in nondemented Parkinson's disease patients
title Patterns of cortical thinning in nondemented Parkinson's disease patients
title_full Patterns of cortical thinning in nondemented Parkinson's disease patients
title_fullStr Patterns of cortical thinning in nondemented Parkinson's disease patients
title_full_unstemmed Patterns of cortical thinning in nondemented Parkinson's disease patients
title_short Patterns of cortical thinning in nondemented Parkinson's disease patients
title_sort patterns of cortical thinning in nondemented parkinson's disease patients
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061099/
https://www.ncbi.nlm.nih.gov/pubmed/27094093
http://dx.doi.org/10.1002/mds.26590
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