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Emerging applications of riboswitches – from antibacterial targets to molecular tools

The ability to precisely regulate gene expression is one of the most important features of the living cells as it enables the adaptation and survival in different environmental conditions. The majority of regulatory mechanisms involve protein action, however, multiple genes are controlled by nucleic...

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Autores principales: Machtel, Piotr, Bąkowska-Żywicka, Kamilla, Żywicki, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061826/
https://www.ncbi.nlm.nih.gov/pubmed/27020791
http://dx.doi.org/10.1007/s13353-016-0341-x
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author Machtel, Piotr
Bąkowska-Żywicka, Kamilla
Żywicki, Marek
author_facet Machtel, Piotr
Bąkowska-Żywicka, Kamilla
Żywicki, Marek
author_sort Machtel, Piotr
collection PubMed
description The ability to precisely regulate gene expression is one of the most important features of the living cells as it enables the adaptation and survival in different environmental conditions. The majority of regulatory mechanisms involve protein action, however, multiple genes are controlled by nucleic acids. Among RNA-based regulators, the riboswitches present a large group of specific domains within messenger RNAs able to respond to small metabolites, tRNA, secondary messengers, ions, vitamins or amino acids. A simple, accurate, and efficient mechanism of action as well as easiness in handling and engineering make the riboswitches a potent practical tool in industry, medicine, pharmacy or environmental protection. Hereby, we summarize the current achievements and challenges in designing and practical employment of the riboswitch-based tools.
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spelling pubmed-50618262016-10-26 Emerging applications of riboswitches – from antibacterial targets to molecular tools Machtel, Piotr Bąkowska-Żywicka, Kamilla Żywicki, Marek J Appl Genet Microbial Genetics • Review The ability to precisely regulate gene expression is one of the most important features of the living cells as it enables the adaptation and survival in different environmental conditions. The majority of regulatory mechanisms involve protein action, however, multiple genes are controlled by nucleic acids. Among RNA-based regulators, the riboswitches present a large group of specific domains within messenger RNAs able to respond to small metabolites, tRNA, secondary messengers, ions, vitamins or amino acids. A simple, accurate, and efficient mechanism of action as well as easiness in handling and engineering make the riboswitches a potent practical tool in industry, medicine, pharmacy or environmental protection. Hereby, we summarize the current achievements and challenges in designing and practical employment of the riboswitch-based tools. Springer Berlin Heidelberg 2016-03-28 2016 /pmc/articles/PMC5061826/ /pubmed/27020791 http://dx.doi.org/10.1007/s13353-016-0341-x Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Microbial Genetics • Review
Machtel, Piotr
Bąkowska-Żywicka, Kamilla
Żywicki, Marek
Emerging applications of riboswitches – from antibacterial targets to molecular tools
title Emerging applications of riboswitches – from antibacterial targets to molecular tools
title_full Emerging applications of riboswitches – from antibacterial targets to molecular tools
title_fullStr Emerging applications of riboswitches – from antibacterial targets to molecular tools
title_full_unstemmed Emerging applications of riboswitches – from antibacterial targets to molecular tools
title_short Emerging applications of riboswitches – from antibacterial targets to molecular tools
title_sort emerging applications of riboswitches – from antibacterial targets to molecular tools
topic Microbial Genetics • Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061826/
https://www.ncbi.nlm.nih.gov/pubmed/27020791
http://dx.doi.org/10.1007/s13353-016-0341-x
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