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Transit times and mean ages for nonautonomous and autonomous compartmental systems

We develop a theory for transit times and mean ages for nonautonomous compartmental systems. Using the McKendrick–von Förster equation, we show that the mean ages of mass in a compartmental system satisfy a linear nonautonomous ordinary differential equation that is exponentially stable. We then def...

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Autores principales: Rasmussen, Martin, Hastings, Alan, Smith, Matthew J., Agusto, Folashade B., Chen-Charpentier, Benito M., Hoffman, Forrest M., Jiang, Jiang, Todd-Brown, Katherine E. O., Wang, Ying, Wang, Ying-Ping, Luo, Yiqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061853/
https://www.ncbi.nlm.nih.gov/pubmed/27038163
http://dx.doi.org/10.1007/s00285-016-0990-8
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author Rasmussen, Martin
Hastings, Alan
Smith, Matthew J.
Agusto, Folashade B.
Chen-Charpentier, Benito M.
Hoffman, Forrest M.
Jiang, Jiang
Todd-Brown, Katherine E. O.
Wang, Ying
Wang, Ying-Ping
Luo, Yiqi
author_facet Rasmussen, Martin
Hastings, Alan
Smith, Matthew J.
Agusto, Folashade B.
Chen-Charpentier, Benito M.
Hoffman, Forrest M.
Jiang, Jiang
Todd-Brown, Katherine E. O.
Wang, Ying
Wang, Ying-Ping
Luo, Yiqi
author_sort Rasmussen, Martin
collection PubMed
description We develop a theory for transit times and mean ages for nonautonomous compartmental systems. Using the McKendrick–von Förster equation, we show that the mean ages of mass in a compartmental system satisfy a linear nonautonomous ordinary differential equation that is exponentially stable. We then define a nonautonomous version of transit time as the mean age of mass leaving the compartmental system at a particular time and show that our nonautonomous theory generalises the autonomous case. We apply these results to study a nine-dimensional nonautonomous compartmental system modeling the terrestrial carbon cycle, which is a modification of the Carnegie–Ames–Stanford approach model, and we demonstrate that the nonautonomous versions of transit time and mean age differ significantly from the autonomous quantities when calculated for that model.
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spelling pubmed-50618532016-10-28 Transit times and mean ages for nonautonomous and autonomous compartmental systems Rasmussen, Martin Hastings, Alan Smith, Matthew J. Agusto, Folashade B. Chen-Charpentier, Benito M. Hoffman, Forrest M. Jiang, Jiang Todd-Brown, Katherine E. O. Wang, Ying Wang, Ying-Ping Luo, Yiqi J Math Biol Article We develop a theory for transit times and mean ages for nonautonomous compartmental systems. Using the McKendrick–von Förster equation, we show that the mean ages of mass in a compartmental system satisfy a linear nonautonomous ordinary differential equation that is exponentially stable. We then define a nonautonomous version of transit time as the mean age of mass leaving the compartmental system at a particular time and show that our nonautonomous theory generalises the autonomous case. We apply these results to study a nine-dimensional nonautonomous compartmental system modeling the terrestrial carbon cycle, which is a modification of the Carnegie–Ames–Stanford approach model, and we demonstrate that the nonautonomous versions of transit time and mean age differ significantly from the autonomous quantities when calculated for that model. Springer Berlin Heidelberg 2016-04-01 2016 /pmc/articles/PMC5061853/ /pubmed/27038163 http://dx.doi.org/10.1007/s00285-016-0990-8 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Rasmussen, Martin
Hastings, Alan
Smith, Matthew J.
Agusto, Folashade B.
Chen-Charpentier, Benito M.
Hoffman, Forrest M.
Jiang, Jiang
Todd-Brown, Katherine E. O.
Wang, Ying
Wang, Ying-Ping
Luo, Yiqi
Transit times and mean ages for nonautonomous and autonomous compartmental systems
title Transit times and mean ages for nonautonomous and autonomous compartmental systems
title_full Transit times and mean ages for nonautonomous and autonomous compartmental systems
title_fullStr Transit times and mean ages for nonautonomous and autonomous compartmental systems
title_full_unstemmed Transit times and mean ages for nonautonomous and autonomous compartmental systems
title_short Transit times and mean ages for nonautonomous and autonomous compartmental systems
title_sort transit times and mean ages for nonautonomous and autonomous compartmental systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061853/
https://www.ncbi.nlm.nih.gov/pubmed/27038163
http://dx.doi.org/10.1007/s00285-016-0990-8
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