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Chemical O‐Glycosylations: An Overview
The development of glycobiology relies on the sources of particular oligosaccharides in their purest forms. As the isolation of the oligosaccharide structures from natural sources is not a reliable option for providing samples with homogeneity, chemical means become pertinent. The growing demand for...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062006/ https://www.ncbi.nlm.nih.gov/pubmed/27777833 http://dx.doi.org/10.1002/open.201600043 |
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author | Das, Rituparna Mukhopadhyay, Balaram |
author_facet | Das, Rituparna Mukhopadhyay, Balaram |
author_sort | Das, Rituparna |
collection | PubMed |
description | The development of glycobiology relies on the sources of particular oligosaccharides in their purest forms. As the isolation of the oligosaccharide structures from natural sources is not a reliable option for providing samples with homogeneity, chemical means become pertinent. The growing demand for diverse oligosaccharide structures has prompted the advancement of chemical strategies to stitch sugar molecules with precise stereo‐ and regioselectivity through the formation of glycosidic bonds. This Review will focus on the key developments towards chemical O‐glycosylations in the current century. Synthesis of novel glycosyl donors and acceptors and their unique activation for successful glycosylation are discussed. This Review concludes with a summary of recent developments and comments on future prospects. |
format | Online Article Text |
id | pubmed-5062006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50620062016-10-24 Chemical O‐Glycosylations: An Overview Das, Rituparna Mukhopadhyay, Balaram ChemistryOpen Reviews The development of glycobiology relies on the sources of particular oligosaccharides in their purest forms. As the isolation of the oligosaccharide structures from natural sources is not a reliable option for providing samples with homogeneity, chemical means become pertinent. The growing demand for diverse oligosaccharide structures has prompted the advancement of chemical strategies to stitch sugar molecules with precise stereo‐ and regioselectivity through the formation of glycosidic bonds. This Review will focus on the key developments towards chemical O‐glycosylations in the current century. Synthesis of novel glycosyl donors and acceptors and their unique activation for successful glycosylation are discussed. This Review concludes with a summary of recent developments and comments on future prospects. John Wiley and Sons Inc. 2016-08-17 /pmc/articles/PMC5062006/ /pubmed/27777833 http://dx.doi.org/10.1002/open.201600043 Text en © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Reviews Das, Rituparna Mukhopadhyay, Balaram Chemical O‐Glycosylations: An Overview |
title | Chemical O‐Glycosylations: An Overview |
title_full | Chemical O‐Glycosylations: An Overview |
title_fullStr | Chemical O‐Glycosylations: An Overview |
title_full_unstemmed | Chemical O‐Glycosylations: An Overview |
title_short | Chemical O‐Glycosylations: An Overview |
title_sort | chemical o‐glycosylations: an overview |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062006/ https://www.ncbi.nlm.nih.gov/pubmed/27777833 http://dx.doi.org/10.1002/open.201600043 |
work_keys_str_mv | AT dasrituparna chemicaloglycosylationsanoverview AT mukhopadhyaybalaram chemicaloglycosylationsanoverview |