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The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding

The interaction between the T cell antigen receptor (TCR) and antigenic peptide in complex with major histocompatibility complex (MHC) molecules is a crucial step in T cell activation. The relative contributions of TCR:peptide and TCR:MHC contacts to the overall binding energy remain unclear. This h...

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Detalles Bibliográficos
Autores principales:	Zhang, Hao, Lim, Hong-Sheng, Knapp, Berhard, Deane, Charlotte M., Aleksic, Milos, Dushek, Omer, van der Merwe, P. Anton
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062128/ https://www.ncbi.nlm.nih.gov/pubmed/27734930 http://dx.doi.org/10.1038/srep35326

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