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Ease of intubation: A randomized, double-blind study to compare two doses of rocuronium bromide for endotracheal intubation

CONTEXT: Clinical need for a nondepolarizing agent with a rapid onset time and a brief duration of action has led to the development of rocuronium bromide. AIMS: The aim of this study was to evaluate optimal dose of rocuronium bromide for intubation and to compare the onset time, duration of action,...

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Autores principales: Shukla, Aparna, Misra, Shilpi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062231/
https://www.ncbi.nlm.nih.gov/pubmed/27746543
http://dx.doi.org/10.4103/0259-1162.179308
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author Shukla, Aparna
Misra, Shilpi
author_facet Shukla, Aparna
Misra, Shilpi
author_sort Shukla, Aparna
collection PubMed
description CONTEXT: Clinical need for a nondepolarizing agent with a rapid onset time and a brief duration of action has led to the development of rocuronium bromide. AIMS: The aim of this study was to evaluate optimal dose of rocuronium bromide for intubation and to compare the onset time, duration of action, intubating conditions, and hemodynamic effects of two doses of rocuronium bromide. SETTINGS AND DESIGN: A prospective, randomized, double-blind study. MATERIALS AND METHODS: All the patients were divided in a randomized, double-blind fashion into two groups of twenty patients each. Group I patients received rocuronium bromide 0.6 mg/kg intravenously and intubated at 60 s, Group II patients received rocuronium bromide 0.9 mg/kg and intubated at 60 s. The neuromuscular block was assessed using single twitch stimulation of 0.1 Hz at adductor pollicis muscle of hand at every 10 s. STATISTICAL ANALYSIS USED: The results were compiled and analyzed statistically using Chi-square test for qualitative data and Student's t-test for quantitative data. RESULTS: Time of onset was significantly shorter (P < 0.01) and duration of action was prolonged (P < 0.001) for Group II as compared to Group I. The intubating conditions were (excellent + good) in 100% patients of Group II and (excellent + good) in 80% of Group I. There was no significant change in pulse rate and mean arterial pressure from the baseline value after the administration of muscle relaxants in either of the two groups. CONCLUSIONS: Rocuronium bromide 0.9 mg/kg is a safer alternative to rocuronium bromide 0.6 mg/kg for endotracheal intubation with shorter time of onset and better intubating conditions.
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spelling pubmed-50622312016-10-14 Ease of intubation: A randomized, double-blind study to compare two doses of rocuronium bromide for endotracheal intubation Shukla, Aparna Misra, Shilpi Anesth Essays Res Original Article CONTEXT: Clinical need for a nondepolarizing agent with a rapid onset time and a brief duration of action has led to the development of rocuronium bromide. AIMS: The aim of this study was to evaluate optimal dose of rocuronium bromide for intubation and to compare the onset time, duration of action, intubating conditions, and hemodynamic effects of two doses of rocuronium bromide. SETTINGS AND DESIGN: A prospective, randomized, double-blind study. MATERIALS AND METHODS: All the patients were divided in a randomized, double-blind fashion into two groups of twenty patients each. Group I patients received rocuronium bromide 0.6 mg/kg intravenously and intubated at 60 s, Group II patients received rocuronium bromide 0.9 mg/kg and intubated at 60 s. The neuromuscular block was assessed using single twitch stimulation of 0.1 Hz at adductor pollicis muscle of hand at every 10 s. STATISTICAL ANALYSIS USED: The results were compiled and analyzed statistically using Chi-square test for qualitative data and Student's t-test for quantitative data. RESULTS: Time of onset was significantly shorter (P < 0.01) and duration of action was prolonged (P < 0.001) for Group II as compared to Group I. The intubating conditions were (excellent + good) in 100% patients of Group II and (excellent + good) in 80% of Group I. There was no significant change in pulse rate and mean arterial pressure from the baseline value after the administration of muscle relaxants in either of the two groups. CONCLUSIONS: Rocuronium bromide 0.9 mg/kg is a safer alternative to rocuronium bromide 0.6 mg/kg for endotracheal intubation with shorter time of onset and better intubating conditions. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5062231/ /pubmed/27746543 http://dx.doi.org/10.4103/0259-1162.179308 Text en Copyright: © Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Shukla, Aparna
Misra, Shilpi
Ease of intubation: A randomized, double-blind study to compare two doses of rocuronium bromide for endotracheal intubation
title Ease of intubation: A randomized, double-blind study to compare two doses of rocuronium bromide for endotracheal intubation
title_full Ease of intubation: A randomized, double-blind study to compare two doses of rocuronium bromide for endotracheal intubation
title_fullStr Ease of intubation: A randomized, double-blind study to compare two doses of rocuronium bromide for endotracheal intubation
title_full_unstemmed Ease of intubation: A randomized, double-blind study to compare two doses of rocuronium bromide for endotracheal intubation
title_short Ease of intubation: A randomized, double-blind study to compare two doses of rocuronium bromide for endotracheal intubation
title_sort ease of intubation: a randomized, double-blind study to compare two doses of rocuronium bromide for endotracheal intubation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062231/
https://www.ncbi.nlm.nih.gov/pubmed/27746543
http://dx.doi.org/10.4103/0259-1162.179308
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