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Palonosetron and granisetron in postoperative nausea vomiting: A randomized double-blind prospective study

BACKGROUND: Postoperative nausea and vomiting (PONV) is a common occurrence after laparoscopic surgeries. A number of pharmacological agents (antihistamines, butyrophenones, dopamine receptor antagonists) have been tried of which the 5-hydroxytryptamine type 3 receptor antagonists are devoid of most...

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Autores principales: Gugale, Amrita A., Bhalerao, Pradnya Milind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062237/
https://www.ncbi.nlm.nih.gov/pubmed/27746523
http://dx.doi.org/10.4103/0259-1162.191121
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author Gugale, Amrita A.
Bhalerao, Pradnya Milind
author_facet Gugale, Amrita A.
Bhalerao, Pradnya Milind
author_sort Gugale, Amrita A.
collection PubMed
description BACKGROUND: Postoperative nausea and vomiting (PONV) is a common occurrence after laparoscopic surgeries. A number of pharmacological agents (antihistamines, butyrophenones, dopamine receptor antagonists) have been tried of which the 5-hydroxytryptamine type 3 receptor antagonists are devoid of most side effects and highly effective in prevention and treatment of PONV. Thus, we evaluated the effectiveness of granisetron and palonosetron in prevention of PONV after laparoscopic surgeries under general anesthesia. AIMS: We conducted a study to evaluate the effectiveness of granisetron and palonosetron, to compare the duration of action and side effects if any, in patients undergoing elective laparoscopic surgery under general anesthesia. SETTINGS AND DESIGN: This was a prospective, randomized, double-blinded, comparative study. Sixty patients (18–65 years of age) of the American Society of Anesthesiologists Grade I and II undergoing elective laparoscopic surgeries were considered. MATERIALS AND METHODS: They were randomly allocated into one of the two groups (Group G and Group P) of thirty patients each. Group G received injection granisetron 0.05 mg/kg; Group P received injection palonosetron 1.5 mcg/kg intravenous bolus 30 min before the induction of anesthesia. STATISTICAL TESTS: All statistical analyses were performed using the SPSS(®) statistical package version 18.0 (Chicago: SPSS Inc). Two independent sample t-test was used for quantitative data, and the χ(2) or Fisher's exact test was used for qualitative data. A difference was regarded as statistically significant at a P < 0.05. RESULTS: The need for rescue antiemetic was significantly lower in Group P in the 24–72 h postoperative period (ρ - 0.007). The PONV score was significantly less in Group P in the same period (ρ - 0.008). The incidence of side effects was statistically insignificant in both the groups (ρ - 0.999). CONCLUSION: Prophylactic therapy with palonosetron is more effective than granisetron in the prevention of PONV after laparoscopic surgeries under general anesthesia.
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spelling pubmed-50622372016-10-14 Palonosetron and granisetron in postoperative nausea vomiting: A randomized double-blind prospective study Gugale, Amrita A. Bhalerao, Pradnya Milind Anesth Essays Res Original Article BACKGROUND: Postoperative nausea and vomiting (PONV) is a common occurrence after laparoscopic surgeries. A number of pharmacological agents (antihistamines, butyrophenones, dopamine receptor antagonists) have been tried of which the 5-hydroxytryptamine type 3 receptor antagonists are devoid of most side effects and highly effective in prevention and treatment of PONV. Thus, we evaluated the effectiveness of granisetron and palonosetron in prevention of PONV after laparoscopic surgeries under general anesthesia. AIMS: We conducted a study to evaluate the effectiveness of granisetron and palonosetron, to compare the duration of action and side effects if any, in patients undergoing elective laparoscopic surgery under general anesthesia. SETTINGS AND DESIGN: This was a prospective, randomized, double-blinded, comparative study. Sixty patients (18–65 years of age) of the American Society of Anesthesiologists Grade I and II undergoing elective laparoscopic surgeries were considered. MATERIALS AND METHODS: They were randomly allocated into one of the two groups (Group G and Group P) of thirty patients each. Group G received injection granisetron 0.05 mg/kg; Group P received injection palonosetron 1.5 mcg/kg intravenous bolus 30 min before the induction of anesthesia. STATISTICAL TESTS: All statistical analyses were performed using the SPSS(®) statistical package version 18.0 (Chicago: SPSS Inc). Two independent sample t-test was used for quantitative data, and the χ(2) or Fisher's exact test was used for qualitative data. A difference was regarded as statistically significant at a P < 0.05. RESULTS: The need for rescue antiemetic was significantly lower in Group P in the 24–72 h postoperative period (ρ - 0.007). The PONV score was significantly less in Group P in the same period (ρ - 0.008). The incidence of side effects was statistically insignificant in both the groups (ρ - 0.999). CONCLUSION: Prophylactic therapy with palonosetron is more effective than granisetron in the prevention of PONV after laparoscopic surgeries under general anesthesia. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5062237/ /pubmed/27746523 http://dx.doi.org/10.4103/0259-1162.191121 Text en Copyright: © Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Gugale, Amrita A.
Bhalerao, Pradnya Milind
Palonosetron and granisetron in postoperative nausea vomiting: A randomized double-blind prospective study
title Palonosetron and granisetron in postoperative nausea vomiting: A randomized double-blind prospective study
title_full Palonosetron and granisetron in postoperative nausea vomiting: A randomized double-blind prospective study
title_fullStr Palonosetron and granisetron in postoperative nausea vomiting: A randomized double-blind prospective study
title_full_unstemmed Palonosetron and granisetron in postoperative nausea vomiting: A randomized double-blind prospective study
title_short Palonosetron and granisetron in postoperative nausea vomiting: A randomized double-blind prospective study
title_sort palonosetron and granisetron in postoperative nausea vomiting: a randomized double-blind prospective study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062237/
https://www.ncbi.nlm.nih.gov/pubmed/27746523
http://dx.doi.org/10.4103/0259-1162.191121
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