Molecular Determinants of Mutant Phenotypes, Inferred from Saturation Mutagenesis Data

Understanding how mutations affect protein activity and organismal fitness is a major challenge. We used saturation mutagenesis combined with deep sequencing to determine mutational sensitivity scores for 1,664 single-site mutants of the 101 residue Escherichia coli cytotoxin, CcdB at seven differen...

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Detalles Bibliográficos
Autores principales: Tripathi, Arti, Gupta, Kritika, Khare, Shruti, Jain, Pankaj C., Patel, Siddharth, Kumar, Prasanth, Pulianmackal, Ajai J., Aghera, Nilesh, Varadarajan, Raghavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062330/
https://www.ncbi.nlm.nih.gov/pubmed/27563054
http://dx.doi.org/10.1093/molbev/msw182

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