The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia

Normalization of altered glutamate neurotransmission through activation of the mGluR2 has emerged as a new approach to treat schizophrenia. These studies describe a potent brain penetrant mGluR2 positive allosteric modulator (PAM), SAR218645. The compound behaves as a selective PAM of mGluR2 in reco...

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Detalles Bibliográficos
Autores principales: Griebel, Guy, Pichat, Philippe, Boulay, Denis, Naimoli, Vanessa, Potestio, Lisa, Featherstone, Robert, Sahni, Sukhveen, Defex, Henry, Desvignes, Christophe, Slowinski, Franck, Vigé, Xavier, Bergis, Olivier E., Sher, Rosy, Kosley, Raymond, Kongsamut, Sathapana, Black, Mark D., Varty, Geoffrey B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062470/
https://www.ncbi.nlm.nih.gov/pubmed/27734956
http://dx.doi.org/10.1038/srep35320

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