Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors

Inhibition of β-secretase BACE1 is considered one of the most promising approaches for treating Alzheimer's disease. Several structurally distinct BACE1 inhibitors have been withdrawn from development after inducing ocular toxicity in animal models, but the target mediating this toxicity has no...

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Detalles Bibliográficos
Autores principales: Zuhl, Andrea M., Nolan, Charles E., Brodney, Michael A., Niessen, Sherry, Atchison, Kevin, Houle, Christopher, Karanian, David A., Ambroise, Claude, Brulet, Jeffrey W., Beck, Elizabeth M., Doran, Shawn D., O'Neill, Brian T., am Ende, Christopher W., Chang, Cheng, Geoghegan, Kieran F., West, Graham M., Judkins, Joshua C., Hou, Xinjun, Riddell, David R., Johnson, Douglas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062570/
https://www.ncbi.nlm.nih.gov/pubmed/27727204
http://dx.doi.org/10.1038/ncomms13042

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