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GBT440 Inhibits Sickling of Sickle Cell Trait Blood Under In Vitro Conditions Mimicking Strenuous Exercise

In sickle cell trait (SCT), hemoglobin A (HbA) and S (HbS) are co-expressed in each red blood cell (RBC). While homozygous expression of HbS (HbSS) leads to polymerization and sickling of RBCs resulting in sickle cell disease (SCD) characterized by hemolytic anemia, painful vaso-occlusive episodes a...

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Detalles Bibliográficos
Autores principales:	Dufu, Kobina, Lehrer-Graiwer, Josh, Ramos, Eleanor, Oksenberg, Donna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PAGEPress Publications, Pavia, Italy 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062624/ https://www.ncbi.nlm.nih.gov/pubmed/27757216 http://dx.doi.org/10.4081/hr.2016.6637

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