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Pathological and immunological characteristics of piglets infected experimentally with a HP-PRRSV TJ strain
BACKGROUND: Porcine reproductive and respiratory syndrome (PRRS) remains a major threat to swine industry all over the world. The aim of this study was to investigate the mechanism of pathogenesis and immune responses caused by a highly pathogenic porcine reproductive and respiratory syndrome virus...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062860/ https://www.ncbi.nlm.nih.gov/pubmed/27733150 http://dx.doi.org/10.1186/s12917-016-0854-x |
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author | Li, Zhenguang He, Yanliang Xu, Xiaoqin Leng, Xue Li, Shufen Wen, Yongjun Wang, Fengxue Xia, Mingqi Cheng, Shipeng Wu, Hua |
author_facet | Li, Zhenguang He, Yanliang Xu, Xiaoqin Leng, Xue Li, Shufen Wen, Yongjun Wang, Fengxue Xia, Mingqi Cheng, Shipeng Wu, Hua |
author_sort | Li, Zhenguang |
collection | PubMed |
description | BACKGROUND: Porcine reproductive and respiratory syndrome (PRRS) remains a major threat to swine industry all over the world. The aim of this study was to investigate the mechanism of pathogenesis and immune responses caused by a highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV). RESULTS: All piglets experimentally infected with a HP-PRRSV TJ strain virus developed typical clinical signs of PRRS. The percentages of CD3(+), CD4(+), and CD8(+) lymphocytes significantly decreased in the infected group as compared to the uninfected control animals (p < 0.01). Total WBC dropped in the infected animals during the experiment. The level of ELISA antibody against PRRSV increased in 7–10 days after infection and then started to decline. Pathological observations demonstrated various degree lesions, bleeding and necrosis in the lungs of the infected piglets. CONCLUSIONS: These results clearly indicated that HP-PRRSV TJ strain infection would activate host humoral immune response at the early period post infection and cause severe pathological damages on lungs and inhibit cellular immune response after infection. |
format | Online Article Text |
id | pubmed-5062860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-50628602016-10-17 Pathological and immunological characteristics of piglets infected experimentally with a HP-PRRSV TJ strain Li, Zhenguang He, Yanliang Xu, Xiaoqin Leng, Xue Li, Shufen Wen, Yongjun Wang, Fengxue Xia, Mingqi Cheng, Shipeng Wu, Hua BMC Vet Res Research Article BACKGROUND: Porcine reproductive and respiratory syndrome (PRRS) remains a major threat to swine industry all over the world. The aim of this study was to investigate the mechanism of pathogenesis and immune responses caused by a highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV). RESULTS: All piglets experimentally infected with a HP-PRRSV TJ strain virus developed typical clinical signs of PRRS. The percentages of CD3(+), CD4(+), and CD8(+) lymphocytes significantly decreased in the infected group as compared to the uninfected control animals (p < 0.01). Total WBC dropped in the infected animals during the experiment. The level of ELISA antibody against PRRSV increased in 7–10 days after infection and then started to decline. Pathological observations demonstrated various degree lesions, bleeding and necrosis in the lungs of the infected piglets. CONCLUSIONS: These results clearly indicated that HP-PRRSV TJ strain infection would activate host humoral immune response at the early period post infection and cause severe pathological damages on lungs and inhibit cellular immune response after infection. BioMed Central 2016-10-12 /pmc/articles/PMC5062860/ /pubmed/27733150 http://dx.doi.org/10.1186/s12917-016-0854-x Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Li, Zhenguang He, Yanliang Xu, Xiaoqin Leng, Xue Li, Shufen Wen, Yongjun Wang, Fengxue Xia, Mingqi Cheng, Shipeng Wu, Hua Pathological and immunological characteristics of piglets infected experimentally with a HP-PRRSV TJ strain |
title | Pathological and immunological characteristics of piglets infected experimentally with a HP-PRRSV TJ strain |
title_full | Pathological and immunological characteristics of piglets infected experimentally with a HP-PRRSV TJ strain |
title_fullStr | Pathological and immunological characteristics of piglets infected experimentally with a HP-PRRSV TJ strain |
title_full_unstemmed | Pathological and immunological characteristics of piglets infected experimentally with a HP-PRRSV TJ strain |
title_short | Pathological and immunological characteristics of piglets infected experimentally with a HP-PRRSV TJ strain |
title_sort | pathological and immunological characteristics of piglets infected experimentally with a hp-prrsv tj strain |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062860/ https://www.ncbi.nlm.nih.gov/pubmed/27733150 http://dx.doi.org/10.1186/s12917-016-0854-x |
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