Cargando…
Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment
Differentiation of mild cognitive impairment from depression in elderly adults is a clinically relevant issue which is not sufficiently solved. Gait and dual task (DT) parameters may have the potential to complement current diagnostic work-up, as both dementia and depression are associated with chan...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062919/ https://www.ncbi.nlm.nih.gov/pubmed/27790136 http://dx.doi.org/10.3389/fnagi.2016.00235 |
_version_ | 1782459875516743680 |
---|---|
author | Metzger, Florian G. Hobert, Markus A. Ehlis, Ann-Christine Hasmann, Sandra E. Hahn, Tim Eschweiler, Gerhard W. Berg, Daniela Fallgatter, Andreas J. Maetzler, Walter |
author_facet | Metzger, Florian G. Hobert, Markus A. Ehlis, Ann-Christine Hasmann, Sandra E. Hahn, Tim Eschweiler, Gerhard W. Berg, Daniela Fallgatter, Andreas J. Maetzler, Walter |
author_sort | Metzger, Florian G. |
collection | PubMed |
description | Differentiation of mild cognitive impairment from depression in elderly adults is a clinically relevant issue which is not sufficiently solved. Gait and dual task (DT) parameters may have the potential to complement current diagnostic work-up, as both dementia and depression are associated with changes of gait and DT parameters. Methods: Seven hundred and four participants of the TREND study (Tübinger evaluation of Risk factors for Early detection of NeuroDegeneration) aged 50–80 years were assessed using the Consortium to Establish a Registry for Alzheimer's Disease Plus test battery for testing cognition and Beck's Depression Inventory for evaluation of depression. Based on these results, four groups were defined: acute depressed (N = 53), cognitively mildly impaired (N = 97), acute depressed, and cognitively mildly impaired (N = 15), and controls (N = 536). Participants underwent a 20 m walk and checking boxes task under single (ST) and DT conditions. ST and DT performance and dual task costs (DTC) were calculated. Due to the typical age of increasing incidence of depressive and also cognitive symptoms, the 7th decade was calculated separately. Results: ST speeds of gait and checking boxes, DT walking speed, and walking DTC were significantly different between groups. Healthy controls were the fastest in all paradigms and cognitively mildly impaired had higher DTC than depressed individuals. Additionally, we constructed a multivariate predictive model differentiating the groups on a single-subject level. Conclusion: DT parameters are simply and comfortably measureable, and DTC can easily be determined. The combination of these parameters allows a differentiation of depressed and cognitively mildly impaired elderly adults. |
format | Online Article Text |
id | pubmed-5062919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50629192016-10-27 Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment Metzger, Florian G. Hobert, Markus A. Ehlis, Ann-Christine Hasmann, Sandra E. Hahn, Tim Eschweiler, Gerhard W. Berg, Daniela Fallgatter, Andreas J. Maetzler, Walter Front Aging Neurosci Neuroscience Differentiation of mild cognitive impairment from depression in elderly adults is a clinically relevant issue which is not sufficiently solved. Gait and dual task (DT) parameters may have the potential to complement current diagnostic work-up, as both dementia and depression are associated with changes of gait and DT parameters. Methods: Seven hundred and four participants of the TREND study (Tübinger evaluation of Risk factors for Early detection of NeuroDegeneration) aged 50–80 years were assessed using the Consortium to Establish a Registry for Alzheimer's Disease Plus test battery for testing cognition and Beck's Depression Inventory for evaluation of depression. Based on these results, four groups were defined: acute depressed (N = 53), cognitively mildly impaired (N = 97), acute depressed, and cognitively mildly impaired (N = 15), and controls (N = 536). Participants underwent a 20 m walk and checking boxes task under single (ST) and DT conditions. ST and DT performance and dual task costs (DTC) were calculated. Due to the typical age of increasing incidence of depressive and also cognitive symptoms, the 7th decade was calculated separately. Results: ST speeds of gait and checking boxes, DT walking speed, and walking DTC were significantly different between groups. Healthy controls were the fastest in all paradigms and cognitively mildly impaired had higher DTC than depressed individuals. Additionally, we constructed a multivariate predictive model differentiating the groups on a single-subject level. Conclusion: DT parameters are simply and comfortably measureable, and DTC can easily be determined. The combination of these parameters allows a differentiation of depressed and cognitively mildly impaired elderly adults. Frontiers Media S.A. 2016-10-13 /pmc/articles/PMC5062919/ /pubmed/27790136 http://dx.doi.org/10.3389/fnagi.2016.00235 Text en Copyright © 2016 Metzger, Hobert, Ehlis, Hasmann, Hahn, Eschweiler, Berg, Fallgatter, Maetzler and the TREND Study team. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Metzger, Florian G. Hobert, Markus A. Ehlis, Ann-Christine Hasmann, Sandra E. Hahn, Tim Eschweiler, Gerhard W. Berg, Daniela Fallgatter, Andreas J. Maetzler, Walter Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment |
title | Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment |
title_full | Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment |
title_fullStr | Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment |
title_full_unstemmed | Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment |
title_short | Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment |
title_sort | dual tasking for the differentiation between depression and mild cognitive impairment |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062919/ https://www.ncbi.nlm.nih.gov/pubmed/27790136 http://dx.doi.org/10.3389/fnagi.2016.00235 |
work_keys_str_mv | AT metzgerfloriang dualtaskingforthedifferentiationbetweendepressionandmildcognitiveimpairment AT hobertmarkusa dualtaskingforthedifferentiationbetweendepressionandmildcognitiveimpairment AT ehlisannchristine dualtaskingforthedifferentiationbetweendepressionandmildcognitiveimpairment AT hasmannsandrae dualtaskingforthedifferentiationbetweendepressionandmildcognitiveimpairment AT hahntim dualtaskingforthedifferentiationbetweendepressionandmildcognitiveimpairment AT eschweilergerhardw dualtaskingforthedifferentiationbetweendepressionandmildcognitiveimpairment AT bergdaniela dualtaskingforthedifferentiationbetweendepressionandmildcognitiveimpairment AT fallgatterandreasj dualtaskingforthedifferentiationbetweendepressionandmildcognitiveimpairment AT maetzlerwalter dualtaskingforthedifferentiationbetweendepressionandmildcognitiveimpairment AT dualtaskingforthedifferentiationbetweendepressionandmildcognitiveimpairment |