Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation

ATF4 is a pro-oncogenic transcription factor whose translation is activated by eIF2 phosphorylation through delayed re-initiation involving two uORFs in the mRNA leader. However, in yeast, the effect of eIF2 phosphorylation can be mimicked by eIF5 overexpression, which turns eIF5 into translational...

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Detalles Bibliográficos
Autores principales: Kozel, Caitlin, Thompson, Brytteny, Hustak, Samantha, Moore, Chelsea, Nakashima, Akio, Singh, Chingakham Ranjit, Reid, Megan, Cox, Christian, Papadopoulos, Evangelos, Luna, Rafael E., Anderson, Abbey, Tagami, Hideaki, Hiraishi, Hiroyuki, Slone, Emily Archer, Yoshino, Ken-ichi, Asano, Masayo, Gillaspie, Sarah, Nietfeld, Jerome, Perchellet, Jean-Pierre, Rothenburg, Stefan, Masai, Hisao, Wagner, Gerhard, Beeser, Alexander, Kikkawa, Ushio, Fleming, Sherry D., Asano, Katsura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062967/
https://www.ncbi.nlm.nih.gov/pubmed/27325740
http://dx.doi.org/10.1093/nar/gkw559

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