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DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach

In eukaryotic cells the CDC7/DBF4 kinase, also known as DBF4-dependent kinase (DDK), is required for the firing of DNA replication origins. CDC7 is also involved in replication stress responses and its depletion sensitises cells to drugs that affect fork progression, including Topoisomerase 2 poison...

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Detalles Bibliográficos
Autores principales:	Wu, Kevin Z. L., Wang, Guan-Nan, Fitzgerald, Jennifer, Quachthithu, Huong, Rainey, Michael D., Cattaneo, Angela, Bachi, Angela, Santocanale, Corrado
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062981/ https://www.ncbi.nlm.nih.gov/pubmed/27407105 http://dx.doi.org/10.1093/nar/gkw626

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