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SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage
SOX9 encodes a transcription factor that governs cell fate specification throughout development and tissue homeostasis. Elevated SOX9 is implicated in the genesis and progression of human tumors by increasing cell proliferation and epithelial-mesenchymal transition. We found that in response to UV i...
Autores principales: | Hong, Xuehui, Liu, Wenyu, Song, Ruipeng, Shah, Jamie J., Feng, Xing, Tsang, Chi Kwan, Morgan, Katherine M., Bunting, Samuel F., Inuzuka, Hiroyuki, Zheng, X. F. Steven, Shen, Zhiyuan, Sabaawy, Hatem E., Liu, LianXin, Pine, Sharon R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062998/ https://www.ncbi.nlm.nih.gov/pubmed/27566146 http://dx.doi.org/10.1093/nar/gkw748 |
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