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Correlation of bistranded clustered abasic DNA lesion processing with structural and dynamic DNA helix distortion

Clustered apurinic/apyrimidinic (AP; abasic) DNA lesions produced by ionizing radiation are by far more cytotoxic than isolated AP lesion entities. The structure and dynamics of a series of seven 23-bp oligonucleotides featuring simple bistranded clustered damage sites, comprising of two AP sites, z...

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Detalles Bibliográficos
Autores principales:	Bignon, Emmanuelle, Gattuso, Hugo, Morell, Christophe, Dehez, François, Georgakilas, Alexandros G., Monari, Antonio, Dumont, Elise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063003/ https://www.ncbi.nlm.nih.gov/pubmed/27587587 http://dx.doi.org/10.1093/nar/gkw773

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