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Comparison of Common Retinal Vessel Caliber Measurement Software and a Conversion Algorithm

PURPOSE: To compare three commonly used retinal vessel caliber measurement software systems, and propose an algorithm for conversion between measurement systems. METHODS: We used 120 retinal photographs to evaluate the agreement between three commonly used software (Retinal Analysis [RA], Integrativ...

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Autores principales: Yip, WanFen, Tham, Yih Chung, Hsu, Wynne, Lee, Mong Li, Klein, Ronald, Klein, Barbara, Ikram, Mohammad Kamran, Wong, Tien Yin, Cheung, Carol Yim-lui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063055/
https://www.ncbi.nlm.nih.gov/pubmed/27752402
http://dx.doi.org/10.1167/tvst.5.5.11
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author Yip, WanFen
Tham, Yih Chung
Hsu, Wynne
Lee, Mong Li
Klein, Ronald
Klein, Barbara
Ikram, Mohammad Kamran
Wong, Tien Yin
Cheung, Carol Yim-lui
author_facet Yip, WanFen
Tham, Yih Chung
Hsu, Wynne
Lee, Mong Li
Klein, Ronald
Klein, Barbara
Ikram, Mohammad Kamran
Wong, Tien Yin
Cheung, Carol Yim-lui
author_sort Yip, WanFen
collection PubMed
description PURPOSE: To compare three commonly used retinal vessel caliber measurement software systems, and propose an algorithm for conversion between measurement systems. METHODS: We used 120 retinal photographs to evaluate the agreement between three commonly used software (Retinal Analysis [RA], Integrative Vessel Analysis [IVAN], and Singapore I Vessel Assessment [SIVA]). Bland-Altman plots were used to evaluate agreement of retinal arteriolar (central retinal artery equivalent, CRAE) and venular (central retinal vein equivalent, CRVE) calibers. Pearson's correlation was used to assess the associations between systemic factors and retinal vessel calibers, and Z-test was used to compare the strength of the correlation coefficients across the three software systems. An algorithm was created to convert measurements, with paired t-test performed to evaluate the differences between SIVA-measured retinal calibers and SIVA-approximates converted from RA- and IVAN-measurements using the algorithm. RESULTS: Differences between SIVA- and RA-measured calibers (CRAE: mean difference [MD] = −21.8 μm, 95% limits of agreement [LOA], −47.3 to 3.7 μm; CRVE: MD = −7.7 μm, 95% LOA, −28.0 to 12.6 μm), SIVA- and IVAN-measured calibers (CRAE: MD = −6.7 μm, 95% LOA, −23.8 to 10.4 μm; CRVE: MD = −18.2 μm 95% LOA, −36.7 to 0.4 μm) were large. However, the strength of correlations between systemic factors with SIVA-measured retinal calibers was not significantly different to that measured using RA and IVAN (P ≥ 0.332). SIVA-approximates converted from RA and IVAN measurements using the proposed algorithm was not significantly different from SIVA-measured calibers (P ≥ 0.20). CONCLUSION: Absolute measurements of retinal vessel calibers vary between three common software systems but associations with systemic factors were similar. TRANSLATIONAL RELEVANCE: The proposed algorithm allowed conversions of RA and IVAN measurements to SIVA-approximates. This conversion is important for future data pooling and establishment of normative values for retinal vascular caliber measurements.
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spelling pubmed-50630552016-10-17 Comparison of Common Retinal Vessel Caliber Measurement Software and a Conversion Algorithm Yip, WanFen Tham, Yih Chung Hsu, Wynne Lee, Mong Li Klein, Ronald Klein, Barbara Ikram, Mohammad Kamran Wong, Tien Yin Cheung, Carol Yim-lui Transl Vis Sci Technol Articles PURPOSE: To compare three commonly used retinal vessel caliber measurement software systems, and propose an algorithm for conversion between measurement systems. METHODS: We used 120 retinal photographs to evaluate the agreement between three commonly used software (Retinal Analysis [RA], Integrative Vessel Analysis [IVAN], and Singapore I Vessel Assessment [SIVA]). Bland-Altman plots were used to evaluate agreement of retinal arteriolar (central retinal artery equivalent, CRAE) and venular (central retinal vein equivalent, CRVE) calibers. Pearson's correlation was used to assess the associations between systemic factors and retinal vessel calibers, and Z-test was used to compare the strength of the correlation coefficients across the three software systems. An algorithm was created to convert measurements, with paired t-test performed to evaluate the differences between SIVA-measured retinal calibers and SIVA-approximates converted from RA- and IVAN-measurements using the algorithm. RESULTS: Differences between SIVA- and RA-measured calibers (CRAE: mean difference [MD] = −21.8 μm, 95% limits of agreement [LOA], −47.3 to 3.7 μm; CRVE: MD = −7.7 μm, 95% LOA, −28.0 to 12.6 μm), SIVA- and IVAN-measured calibers (CRAE: MD = −6.7 μm, 95% LOA, −23.8 to 10.4 μm; CRVE: MD = −18.2 μm 95% LOA, −36.7 to 0.4 μm) were large. However, the strength of correlations between systemic factors with SIVA-measured retinal calibers was not significantly different to that measured using RA and IVAN (P ≥ 0.332). SIVA-approximates converted from RA and IVAN measurements using the proposed algorithm was not significantly different from SIVA-measured calibers (P ≥ 0.20). CONCLUSION: Absolute measurements of retinal vessel calibers vary between three common software systems but associations with systemic factors were similar. TRANSLATIONAL RELEVANCE: The proposed algorithm allowed conversions of RA and IVAN measurements to SIVA-approximates. This conversion is important for future data pooling and establishment of normative values for retinal vascular caliber measurements. The Association for Research in Vision and Ophthalmology 2016-10-12 /pmc/articles/PMC5063055/ /pubmed/27752402 http://dx.doi.org/10.1167/tvst.5.5.11 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Articles
Yip, WanFen
Tham, Yih Chung
Hsu, Wynne
Lee, Mong Li
Klein, Ronald
Klein, Barbara
Ikram, Mohammad Kamran
Wong, Tien Yin
Cheung, Carol Yim-lui
Comparison of Common Retinal Vessel Caliber Measurement Software and a Conversion Algorithm
title Comparison of Common Retinal Vessel Caliber Measurement Software and a Conversion Algorithm
title_full Comparison of Common Retinal Vessel Caliber Measurement Software and a Conversion Algorithm
title_fullStr Comparison of Common Retinal Vessel Caliber Measurement Software and a Conversion Algorithm
title_full_unstemmed Comparison of Common Retinal Vessel Caliber Measurement Software and a Conversion Algorithm
title_short Comparison of Common Retinal Vessel Caliber Measurement Software and a Conversion Algorithm
title_sort comparison of common retinal vessel caliber measurement software and a conversion algorithm
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063055/
https://www.ncbi.nlm.nih.gov/pubmed/27752402
http://dx.doi.org/10.1167/tvst.5.5.11
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