Cargando…

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo

Bacterial metallo-β-lactamases (MBLs) are involved in resistance to β-lactam antibiotics including cephalosporins. Human SNM1A and SNM1B are MBL superfamily exonucleases that play a key role in the repair of DNA interstrand cross-links, which are induced by antitumour chemotherapeutics, and are ther...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Sook Y., Brem, Jürgen, Pettinati, Ilaria, Claridge, Timothy D. W., Gileadi, Opher, Schofield, Christopher J., McHugh, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063058/ https://www.ncbi.nlm.nih.gov/pubmed/27121860 http://dx.doi.org/10.1039/c6cc00529b

Ejemplares similares

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities
por: Allerston, Charles K., et al.
Publicado: (2015)

Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases
por: Sengerová, Blanka, et al.
Publicado: (2012)

The SNM1A DNA repair nuclease
por: Baddock, Hannah T., et al.
Publicado: (2020)

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family
por: Baddock, Hannah T, et al.
Publicado: (2021)

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing
por: Iyama, Teruaki, et al.
Publicado: (2015)

SNM1B/Apollo in the DNA damage response and telomere maintenance
por: Schmiester, Maren, et al.
Publicado: (2017)

The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins
por: Pettinati, Ilaria, et al.
Publicado: (2016)

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
por: Doherty, William, et al.
Publicado: (2019)

Probing the Binding Requirements of Modified Nucleosides with the DNA Nuclease SNM1A
por: Dürr, Eva-Maria, et al.
Publicado: (2021)

Message from SNM President
por: Mittal, BR
Publicado: (2010)

Message by President, SNM, India
por: Kumar, Rakesh
Publicado: (2019)

Snm1B Interacts with PSF2
por: Stringer, Jay R., et al.
Publicado: (2012)

Identification of Bioactive SNM1A Inhibitors
por: Buzon, Beverlee, et al.
Publicado: (2021)

Message by President Elect, SNM, India
por: Singh, Baljinder
Publicado: (2019)

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers
por: Brem, Jürgen, et al.
Publicado: (2015)

Squaramide‐Based 5’‐Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A
por: Dürr, Eva‐Maria, et al.
Publicado: (2018)

The hSNM1 protein is a DNA 5′-exonuclease
por: Hejna, James, et al.
Publicado: (2007)

Pso2 (SNM1) is a DNA structure-specific endonuclease
por: Tiefenbach, Tracy, et al.
Publicado: (2012)

Synthesis and evaluation of squaramide and thiosquaramide inhibitors of the DNA repair enzyme SNM1A
por: Berney, Mark, et al.
Publicado: (2021)

Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport
por: Song, Shang, et al.
Publicado: (2016)

Robust single-cell DNA methylome profiling with snmC-seq2
por: Luo, Chongyuan, et al.
Publicado: (2018)

Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink
por: Buzon, Beverlee, et al.
Publicado: (2018)

Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features
por: Karim, Md Fazlul, et al.
Publicado: (2020)

MNM and SNM maintain but do not establish achiasmate homolog conjunction during Drosophila male meiosis
por: Sun, Michael Shoujie, et al.
Publicado: (2019)

One‐year outcomes of the ARTISAN‐SNM study with the Axonics System for the treatment of urinary urgency incontinence
por: Benson, Kevin, et al.
Publicado: (2020)

Monitoring Conformational Changes in the NDM-1 Metallo-β-lactamase by (19)F NMR Spectroscopy**
por: Rydzik, Anna M, et al.
Publicado: (2014)

Interaction of Avibactam with Class B Metallo-β-Lactamases
por: Abboud, Martine I., et al.
Publicado: (2016)

Cyclobutanone Mimics of Intermediates in Metallo‐β‐Lactamase Catalysis
por: Abboud, Martine I., et al.
Publicado: (2018)

Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease
por: Levy, Shiri, et al.
Publicado: (2016)

Monitoring protein-metal binding by (19)F NMR – a case study with the New Delhi metallo-β-lactamase 1
por: Rydzik, Anna M., et al.
Publicado: (2020)

Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1
por: Brem, Jürgen, et al.
Publicado: (2015)

Use of ferrous iron by metallo-β-lactamases
por: Cahill, Samuel T., et al.
Publicado: (2016)

Two‐year outcomes of the ARTISAN‐SNM study for the treatment of urinary urgency incontinence using the Axonics rechargeable sacral neuromodulation system
por: Pezzella, Andrea, et al.
Publicado: (2021)

Cephalosporin Prodrug Inhibitors Overcome Metallo‐β‐Lactamase Driven Antibiotic Resistance
por: van Haren, Matthijs J., et al.
Publicado: (2021)

Revealing electronic features governing hydrolysis of cephalosporins in the active site of the L1 metallo-β-lactamase
por: Levina, Elena O., et al.
Publicado: (2020)

Profiling interactions of vaborbactam with metallo-β-lactamases
por: Langley, Gareth W., et al.
Publicado: (2019)

A Modified Semi-Nested Multiplex Malaria PCR (SnM-PCR) for the Identification of the Five Human Plasmodium Species Occurring in Southeast Asia
por: Van Hong, Nguyen, et al.
Publicado: (2013)

Assay Platform for Clinically Relevant Metallo-β-lactamases
por: van Berkel, Sander S., et al.
Publicado: (2013)

Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2
por: Lucic, Anka, et al.
Publicado: (2022)

Assessment of Needs in Children Suffering From Refractory Non-neurogenic Urinary and Fecal Incontinence and Their Caregivers' Needs and Attitudes Toward Alternative Therapies (SNM, TENS)
por: Dos Santos, Joana, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2ji5iqh1d5o8mthe4qr17pr9k0