Fighting Cancer with Transition Metal Complexes: From Naked DNA to Protein and Chromatin Targeting Strategies

Many transition metal complexes have unique physicochemical properties that can be efficiently exploited in medicinal chemistry for cancer treatment. Traditionally, double‐stranded DNA has been assumed to be the main binding target; however, recent studies have shown that nucleosomal DNA as well as...

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Detalles Bibliográficos
Autores principales: Palermo, Giulia, Magistrato, Alessandra, Riedel, Tina, von Erlach, Thibaud, Davey, Curt A., Dyson, Paul J., Rothlisberger, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063137/
https://www.ncbi.nlm.nih.gov/pubmed/26634638
http://dx.doi.org/10.1002/cmdc.201500478

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