The role of osteoclasts in breast cancer bone metastasis

Breast cancer frequently metastasises to the skeleton, interfering with the normal bone remodelling process and inducing bone degradation. Bone degradation is caused by osteoclasts, the normal bone-resorbing cells. Osteoclast-mediated bone degradation subsequently leads to the release of bone-derive...

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Detalles Bibliográficos
Autores principales: Le Pape, François, Vargas, Geoffrey, Clézardin, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063222/
https://www.ncbi.nlm.nih.gov/pubmed/27761364
http://dx.doi.org/10.1016/j.jbo.2016.02.008
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author Le Pape, François
Vargas, Geoffrey
Clézardin, Philippe
author_facet Le Pape, François
Vargas, Geoffrey
Clézardin, Philippe
author_sort Le Pape, François
collection PubMed
description Breast cancer frequently metastasises to the skeleton, interfering with the normal bone remodelling process and inducing bone degradation. Bone degradation is caused by osteoclasts, the normal bone-resorbing cells. Osteoclast-mediated bone degradation subsequently leads to the release of bone-derived factors that promote skeletal tumour growth. Osteoclasts themselves stimulate tumour growth. This Review describes the molecular mechanisms through which osteoclasts and breast cancer cells collaborate with each other, triggering the formation of osteolytic bone metastasis.
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spelling pubmed-50632222016-10-19 The role of osteoclasts in breast cancer bone metastasis Le Pape, François Vargas, Geoffrey Clézardin, Philippe J Bone Oncol Research Paper Breast cancer frequently metastasises to the skeleton, interfering with the normal bone remodelling process and inducing bone degradation. Bone degradation is caused by osteoclasts, the normal bone-resorbing cells. Osteoclast-mediated bone degradation subsequently leads to the release of bone-derived factors that promote skeletal tumour growth. Osteoclasts themselves stimulate tumour growth. This Review describes the molecular mechanisms through which osteoclasts and breast cancer cells collaborate with each other, triggering the formation of osteolytic bone metastasis. Elsevier 2016-04-08 /pmc/articles/PMC5063222/ /pubmed/27761364 http://dx.doi.org/10.1016/j.jbo.2016.02.008 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Paper
Le Pape, François
Vargas, Geoffrey
Clézardin, Philippe
The role of osteoclasts in breast cancer bone metastasis
title The role of osteoclasts in breast cancer bone metastasis
title_full The role of osteoclasts in breast cancer bone metastasis
title_fullStr The role of osteoclasts in breast cancer bone metastasis
title_full_unstemmed The role of osteoclasts in breast cancer bone metastasis
title_short The role of osteoclasts in breast cancer bone metastasis
title_sort role of osteoclasts in breast cancer bone metastasis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063222/
https://www.ncbi.nlm.nih.gov/pubmed/27761364
http://dx.doi.org/10.1016/j.jbo.2016.02.008
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