The role of hematopoietic stem cell niche in prostate cancer bone metastasis

Approximately 80% of prostate cancers exhibit some degree of bone metastasis. The role of the bone marrow and the hematopoietic stem cell (HSC) niche in attracting metastatic cells and maintaining dormancy of disseminated tumor cells (DTCs) is an increasingly important topic towards the development...

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Detalles Bibliográficos
Autores principales: Decker, A.M., Jung, Y., Cackowski, F., Taichman, R.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063229/
https://www.ncbi.nlm.nih.gov/pubmed/27761370
http://dx.doi.org/10.1016/j.jbo.2016.02.005
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author Decker, A.M.
Jung, Y.
Cackowski, F.
Taichman, R.S.
author_facet Decker, A.M.
Jung, Y.
Cackowski, F.
Taichman, R.S.
author_sort Decker, A.M.
collection PubMed
description Approximately 80% of prostate cancers exhibit some degree of bone metastasis. The role of the bone marrow and the hematopoietic stem cell (HSC) niche in attracting metastatic cells and maintaining dormancy of disseminated tumor cells (DTCs) is an increasingly important topic towards the development of novel prostate cancer therapies. This paper reviews aspects of the HSC niche that lead to prostate cancer cell homing and dormancy in the bone marrow. This review also discusses the role of DTCs in the niche environment and discusses the role of erythropoietin in targeting DTCs within the HSC niche.
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spelling pubmed-50632292016-10-19 The role of hematopoietic stem cell niche in prostate cancer bone metastasis Decker, A.M. Jung, Y. Cackowski, F. Taichman, R.S. J Bone Oncol Research Paper Approximately 80% of prostate cancers exhibit some degree of bone metastasis. The role of the bone marrow and the hematopoietic stem cell (HSC) niche in attracting metastatic cells and maintaining dormancy of disseminated tumor cells (DTCs) is an increasingly important topic towards the development of novel prostate cancer therapies. This paper reviews aspects of the HSC niche that lead to prostate cancer cell homing and dormancy in the bone marrow. This review also discusses the role of DTCs in the niche environment and discusses the role of erythropoietin in targeting DTCs within the HSC niche. Elsevier 2016-02-19 /pmc/articles/PMC5063229/ /pubmed/27761370 http://dx.doi.org/10.1016/j.jbo.2016.02.005 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Decker, A.M.
Jung, Y.
Cackowski, F.
Taichman, R.S.
The role of hematopoietic stem cell niche in prostate cancer bone metastasis
title The role of hematopoietic stem cell niche in prostate cancer bone metastasis
title_full The role of hematopoietic stem cell niche in prostate cancer bone metastasis
title_fullStr The role of hematopoietic stem cell niche in prostate cancer bone metastasis
title_full_unstemmed The role of hematopoietic stem cell niche in prostate cancer bone metastasis
title_short The role of hematopoietic stem cell niche in prostate cancer bone metastasis
title_sort role of hematopoietic stem cell niche in prostate cancer bone metastasis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063229/
https://www.ncbi.nlm.nih.gov/pubmed/27761370
http://dx.doi.org/10.1016/j.jbo.2016.02.005
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