The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis()()

Most deaths from solid cancers occur as a result of secondary metastasis to distant sites. Bone is the most frequent metastatic site for many cancer types and can account for up to 80% of cancer-related deaths in certain tumours. The progression from a discrete solid primary tumour to devastating an...

Descripción completa

Detalles Bibliográficos
Autores principales: Gartland, Alison, Erler, Janine T., Cox, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063254/
https://www.ncbi.nlm.nih.gov/pubmed/27761366
http://dx.doi.org/10.1016/j.jbo.2016.04.001
_version_ 1782459934875582464
author Gartland, Alison
Erler, Janine T.
Cox, Thomas R.
author_facet Gartland, Alison
Erler, Janine T.
Cox, Thomas R.
author_sort Gartland, Alison
collection PubMed
description Most deaths from solid cancers occur as a result of secondary metastasis to distant sites. Bone is the most frequent metastatic site for many cancer types and can account for up to 80% of cancer-related deaths in certain tumours. The progression from a discrete solid primary tumour to devastating and painful bone metastases is a complex process involving multiple cell types and steps. There is increasing evidence that modulation of the extracellular matrix plays an important role in the lethal transition from a primary to disseminated metastatic bone tumour. This review provides an overview of the current understanding on the role of role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis
format Online
Article
Text
id pubmed-5063254
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-50632542016-10-19 The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis()() Gartland, Alison Erler, Janine T. Cox, Thomas R. J Bone Oncol Research Paper Most deaths from solid cancers occur as a result of secondary metastasis to distant sites. Bone is the most frequent metastatic site for many cancer types and can account for up to 80% of cancer-related deaths in certain tumours. The progression from a discrete solid primary tumour to devastating and painful bone metastases is a complex process involving multiple cell types and steps. There is increasing evidence that modulation of the extracellular matrix plays an important role in the lethal transition from a primary to disseminated metastatic bone tumour. This review provides an overview of the current understanding on the role of role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis Elsevier 2016-07-01 /pmc/articles/PMC5063254/ /pubmed/27761366 http://dx.doi.org/10.1016/j.jbo.2016.04.001 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Gartland, Alison
Erler, Janine T.
Cox, Thomas R.
The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis()()
title The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis()()
title_full The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis()()
title_fullStr The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis()()
title_full_unstemmed The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis()()
title_short The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis()()
title_sort role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis()()
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063254/
https://www.ncbi.nlm.nih.gov/pubmed/27761366
http://dx.doi.org/10.1016/j.jbo.2016.04.001
work_keys_str_mv AT gartlandalison theroleoflysyloxidasetheextracellularmatrixandthepremetastaticnicheinbonemetastasis
AT erlerjaninet theroleoflysyloxidasetheextracellularmatrixandthepremetastaticnicheinbonemetastasis
AT coxthomasr theroleoflysyloxidasetheextracellularmatrixandthepremetastaticnicheinbonemetastasis
AT gartlandalison roleoflysyloxidasetheextracellularmatrixandthepremetastaticnicheinbonemetastasis
AT erlerjaninet roleoflysyloxidasetheextracellularmatrixandthepremetastaticnicheinbonemetastasis
AT coxthomasr roleoflysyloxidasetheextracellularmatrixandthepremetastaticnicheinbonemetastasis

Ejemplares similares