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Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer

Endometrial cancer is one of the most common malignancies of the reproductive female tract, with endometrioid endometrial cancer being the most frequent type. Despite the relatively favourable prognosis in cases of endometrial cancer, there is a necessity to evaluate clinical and prognostic utility...

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Autores principales: Wilczynski, Milosz, Danielska, Justyna, Dzieniecka, Monika, Szymanska, Bozena, Wojciechowski, Michal, Malinowski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063284/
https://www.ncbi.nlm.nih.gov/pubmed/27737015
http://dx.doi.org/10.1371/journal.pone.0164687
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author Wilczynski, Milosz
Danielska, Justyna
Dzieniecka, Monika
Szymanska, Bozena
Wojciechowski, Michal
Malinowski, Andrzej
author_facet Wilczynski, Milosz
Danielska, Justyna
Dzieniecka, Monika
Szymanska, Bozena
Wojciechowski, Michal
Malinowski, Andrzej
author_sort Wilczynski, Milosz
collection PubMed
description Endometrial cancer is one of the most common malignancies of the reproductive female tract, with endometrioid endometrial cancer being the most frequent type. Despite the relatively favourable prognosis in cases of endometrial cancer, there is a necessity to evaluate clinical and prognostic utility of new molecular markers. MiRNAs are small, non-coding RNA molecules that take part in RNA silencing and post-transcriptional regulation of gene expression. Altered expression of miRNAs may be associated with cancer initiation, progression and metastatic capabilities. MiRNA-205 seems to be one of the key regulators of gene expression in endometrial cancer. In this study, we investigated clinical and prognostic role of miRNA-205 in endometrioid endometrial cancer. After total RNA extraction from 100 archival formalin-fixed paraffin-embedded tissues, real-time quantitative RT-PCR was used to define miRNA-205 expression levels. The aim of the study was to evaluate miRNA-205 expression levels in regard to patients’ clinical and histopathological features, such as: survival rate, recurrence rate, staging, myometrial invasion, grading and lymph nodes involvement. Higher levels of miRNA-205 expression were observed in tumours with less than half of myometrial invasion and non-advanced cancers. Kaplan-Maier analysis revealed that higher levels of miRNA-205 were associated with better overall survival (p = 0,034). These results indicate potential clinical utility of miRNA-205 as a prognostic marker.
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spelling pubmed-50632842016-11-04 Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer Wilczynski, Milosz Danielska, Justyna Dzieniecka, Monika Szymanska, Bozena Wojciechowski, Michal Malinowski, Andrzej PLoS One Research Article Endometrial cancer is one of the most common malignancies of the reproductive female tract, with endometrioid endometrial cancer being the most frequent type. Despite the relatively favourable prognosis in cases of endometrial cancer, there is a necessity to evaluate clinical and prognostic utility of new molecular markers. MiRNAs are small, non-coding RNA molecules that take part in RNA silencing and post-transcriptional regulation of gene expression. Altered expression of miRNAs may be associated with cancer initiation, progression and metastatic capabilities. MiRNA-205 seems to be one of the key regulators of gene expression in endometrial cancer. In this study, we investigated clinical and prognostic role of miRNA-205 in endometrioid endometrial cancer. After total RNA extraction from 100 archival formalin-fixed paraffin-embedded tissues, real-time quantitative RT-PCR was used to define miRNA-205 expression levels. The aim of the study was to evaluate miRNA-205 expression levels in regard to patients’ clinical and histopathological features, such as: survival rate, recurrence rate, staging, myometrial invasion, grading and lymph nodes involvement. Higher levels of miRNA-205 expression were observed in tumours with less than half of myometrial invasion and non-advanced cancers. Kaplan-Maier analysis revealed that higher levels of miRNA-205 were associated with better overall survival (p = 0,034). These results indicate potential clinical utility of miRNA-205 as a prognostic marker. Public Library of Science 2016-10-13 /pmc/articles/PMC5063284/ /pubmed/27737015 http://dx.doi.org/10.1371/journal.pone.0164687 Text en © 2016 Wilczynski et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Wilczynski, Milosz
Danielska, Justyna
Dzieniecka, Monika
Szymanska, Bozena
Wojciechowski, Michal
Malinowski, Andrzej
Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer
title Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer
title_full Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer
title_fullStr Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer
title_full_unstemmed Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer
title_short Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer
title_sort prognostic and clinical significance of mirna-205 in endometrioid endometrial cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063284/
https://www.ncbi.nlm.nih.gov/pubmed/27737015
http://dx.doi.org/10.1371/journal.pone.0164687
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