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Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer
Endometrial cancer is one of the most common malignancies of the reproductive female tract, with endometrioid endometrial cancer being the most frequent type. Despite the relatively favourable prognosis in cases of endometrial cancer, there is a necessity to evaluate clinical and prognostic utility...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063284/ https://www.ncbi.nlm.nih.gov/pubmed/27737015 http://dx.doi.org/10.1371/journal.pone.0164687 |
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author | Wilczynski, Milosz Danielska, Justyna Dzieniecka, Monika Szymanska, Bozena Wojciechowski, Michal Malinowski, Andrzej |
author_facet | Wilczynski, Milosz Danielska, Justyna Dzieniecka, Monika Szymanska, Bozena Wojciechowski, Michal Malinowski, Andrzej |
author_sort | Wilczynski, Milosz |
collection | PubMed |
description | Endometrial cancer is one of the most common malignancies of the reproductive female tract, with endometrioid endometrial cancer being the most frequent type. Despite the relatively favourable prognosis in cases of endometrial cancer, there is a necessity to evaluate clinical and prognostic utility of new molecular markers. MiRNAs are small, non-coding RNA molecules that take part in RNA silencing and post-transcriptional regulation of gene expression. Altered expression of miRNAs may be associated with cancer initiation, progression and metastatic capabilities. MiRNA-205 seems to be one of the key regulators of gene expression in endometrial cancer. In this study, we investigated clinical and prognostic role of miRNA-205 in endometrioid endometrial cancer. After total RNA extraction from 100 archival formalin-fixed paraffin-embedded tissues, real-time quantitative RT-PCR was used to define miRNA-205 expression levels. The aim of the study was to evaluate miRNA-205 expression levels in regard to patients’ clinical and histopathological features, such as: survival rate, recurrence rate, staging, myometrial invasion, grading and lymph nodes involvement. Higher levels of miRNA-205 expression were observed in tumours with less than half of myometrial invasion and non-advanced cancers. Kaplan-Maier analysis revealed that higher levels of miRNA-205 were associated with better overall survival (p = 0,034). These results indicate potential clinical utility of miRNA-205 as a prognostic marker. |
format | Online Article Text |
id | pubmed-5063284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50632842016-11-04 Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer Wilczynski, Milosz Danielska, Justyna Dzieniecka, Monika Szymanska, Bozena Wojciechowski, Michal Malinowski, Andrzej PLoS One Research Article Endometrial cancer is one of the most common malignancies of the reproductive female tract, with endometrioid endometrial cancer being the most frequent type. Despite the relatively favourable prognosis in cases of endometrial cancer, there is a necessity to evaluate clinical and prognostic utility of new molecular markers. MiRNAs are small, non-coding RNA molecules that take part in RNA silencing and post-transcriptional regulation of gene expression. Altered expression of miRNAs may be associated with cancer initiation, progression and metastatic capabilities. MiRNA-205 seems to be one of the key regulators of gene expression in endometrial cancer. In this study, we investigated clinical and prognostic role of miRNA-205 in endometrioid endometrial cancer. After total RNA extraction from 100 archival formalin-fixed paraffin-embedded tissues, real-time quantitative RT-PCR was used to define miRNA-205 expression levels. The aim of the study was to evaluate miRNA-205 expression levels in regard to patients’ clinical and histopathological features, such as: survival rate, recurrence rate, staging, myometrial invasion, grading and lymph nodes involvement. Higher levels of miRNA-205 expression were observed in tumours with less than half of myometrial invasion and non-advanced cancers. Kaplan-Maier analysis revealed that higher levels of miRNA-205 were associated with better overall survival (p = 0,034). These results indicate potential clinical utility of miRNA-205 as a prognostic marker. Public Library of Science 2016-10-13 /pmc/articles/PMC5063284/ /pubmed/27737015 http://dx.doi.org/10.1371/journal.pone.0164687 Text en © 2016 Wilczynski et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Wilczynski, Milosz Danielska, Justyna Dzieniecka, Monika Szymanska, Bozena Wojciechowski, Michal Malinowski, Andrzej Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer |
title | Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer |
title_full | Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer |
title_fullStr | Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer |
title_full_unstemmed | Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer |
title_short | Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer |
title_sort | prognostic and clinical significance of mirna-205 in endometrioid endometrial cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063284/ https://www.ncbi.nlm.nih.gov/pubmed/27737015 http://dx.doi.org/10.1371/journal.pone.0164687 |
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