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Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity

Aldehyde dehydrogenase (ALDH) 2 is a mitochondrial isozyme of the heart involved in the metabolism of toxic aldehydes produced from oxidative stress. We hypothesized that hyperglycemia-mediated decrease in ALDH2 activity may impair mitochondrial respiration and ultimately result in cardiac damage. A...

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Detalles Bibliográficos
Autores principales:	Mali, Vishal R., Pan, Guodong, Deshpande, Mandar, Thandavarayan, Rajarajan A., Xu, Jiang, Yang, Xiao-Ping, Palaniyandi, Suresh S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063328/ https://www.ncbi.nlm.nih.gov/pubmed/27736868 http://dx.doi.org/10.1371/journal.pone.0163158

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