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Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells

Spinal muscular atrophy (SMA) is an intractable neurodegenerative disease afflicting 1 in 6–10,000 live births. One of the key functions of the SMN protein is regulation of spliceosome assembly. Reduced levels of the SMN protein that are observed in SMA have been shown to result in aberrant mRNA spl...

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Detalles Bibliográficos
Autores principales:	Custer, Sara K., Gilson, Timra D., Li, Hongxia, Todd, A. Gary, Astroski, Jacob W., Lin, Hai, Liu, Yunlong, Androphy, Elliot J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063418/ https://www.ncbi.nlm.nih.gov/pubmed/27736905 http://dx.doi.org/10.1371/journal.pone.0163954

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