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Fluorescent Protein-Based Ca(2+) Sensor Reveals Global, Divalent Cation-Dependent Conformational Changes in Cardiac Troponin C

Cardiac troponin C (cTnC) is a key effector in cardiac muscle excitation-contraction coupling as the Ca(2+) sensing subunit responsible for controlling contraction. In this study, we generated several FRET sensors for divalent cations based on cTnC flanked by a donor fluorescent protein (CFP) and an...

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Detalles Bibliográficos
Autores principales:	Badr, Myriam A., Pinto, Jose R., Davidson, Michael W., Chase, P. Bryant
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063504/ https://www.ncbi.nlm.nih.gov/pubmed/27736894 http://dx.doi.org/10.1371/journal.pone.0164222

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